Developmental Exposure to a Mixture of Unconventional Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge
Developmental Exposure to a Mixture of Unconventional Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge
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DOI：
10.3389/fendo.2019.00460
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发表时间：
2019-07-25
影响因子：
5.2
通讯作者：
Nagel, Susan C.
中科院分区：
文献类型：
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作者：
Balise, Victoria D.;Cornelius-Green, Jennifer N.;Nagel, Susan C.
非常规石油和天然气作业中使用的化学品可作为内分泌干扰物和代谢干扰物。我们的实验室报告了C57BIAJ小鼠的能量消耗和活动的改变，这些小鼠在怀孕第1天至出生后第21天通过母体饮用水在怀孕前、妊娠期和哺乳期暴露于实验室产生的23种UOG化学物质的混合物中，7个月大的雌性小鼠的身体组成没有变化。我们假设，让老鼠变老并让它们接触高脂肪、高糖饮食可能会揭示能量平衡的潜在变化。为了研究衰老和代谢挑战是否会加剧这种表型，这些小鼠年龄为12个月，并给予高脂肪高糖饮食（HFHSD）挑战。短暂的3天HFHSD攻击增加了所有小鼠的体重和空腹血糖。发育暴露于23 UOG混合物与光周期中活动和非静息能量消耗增加、高架十字迷宫试验中探索行为增加以及12月龄雌性小鼠睡眠减少相关。这些效应中的每一种都在小鼠通常不太活跃的光周期中观察到。需要进一步的研究，以更好地了解发育暴露于UOG化学品后观察到的行为变化。
Chemicals used in unconventional oil and gas (UOG) operations can act as endocrine disrupting chemicals and metabolic disruptors. Our lab has reported altered energy expenditure and activity in C57BIAJ mice that were preconceptionally, gestationally, and lactationally exposed via maternal drinking water to a laboratory-created mixture of 23 UOG chemicals from gestational day 1 to postnatal day 21 in 7-month-old female mice with no change in body composition. We hypothesized that allowing the mice to age and exposing them to a high fat, high sugar diet might reveal underlying changes in energy balance. To investigate whether aging and metabolic challenge would exacerbate this phenotype, these mice were aged to 12 months and given a high fat, high sugar diet (HFHSD) challenge. The short 3-day HFHSD challenge increased body weight and fasting blood glucose in all mice. Developmental exposure to the 23 UOG mixture was associated with increased activity and non-resting energy expenditure in the light cycle, increased exploratory behavior in the elevated plus maze test, and decreased sleep in 12 month female mice. Each of these effects was seen in the light cycle when mice are normally less active. Further studies are needed to better understand the behavioral changes observed after developmental exposure to UOG chemicals.