Neuroglobin, a Factor Playing for Nerve Cell Survival.
Neuroglobin, a Factor Playing for Nerve Cell Survival.
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DOI：
10.3390/ijms17111817
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发表时间：
2016-10-31
影响因子：
5.6
通讯作者：
Agnati LF
中科院分区：
文献类型：
--
作者：
Guidolin D;Tortorella C;Marcoli M;Maura G;Agnati LF
细胞死亡代表了中枢神经系统几种病理状况的最终结果，现有证据表明，在急性损伤和神经退行性疾病中，细胞死亡通常与线粒体功能障碍有关。因此，阻止参与细胞死亡的线粒体事件的可能性可能是限制神经元损伤的有效工具。近年来，越来越多的证据表明，在各种细胞损伤的实验模型中，内源性蛋白neuroglobin的高表达与线粒体功能的保存以及神经细胞在体外和体内的存活率增加有关，因此，人们越来越关注神经球蛋白。本文将简要讨论神经红蛋白的生物学和结构特征，以及神经红蛋白诱导的神经保护的线粒体相关机制。在这方面，抑制细胞凋亡的内在途径是由蛋白质诱导的关键神经保护作用。这些发现可能为开发有效的神经球蛋白介导的治疗策略提供可能性，旨在最大限度地减少影响中风和神经退行性疾病等神经病理中发生的神经元细胞死亡。
Cell death represents the final outcome of several pathological conditions of the central nervous system and available evidence suggests that in both acute injuries and neurodegenerative diseases it is often associated with mitochondrial dysfunction. Thus, the possibility to prevent mitochondrial events involved in cell death might represent efficient tools to limit neuronal damage. In recent years, increased attention has been paid to the endogenous protein neuroglobin, since accumulating evidence showed that its high expression was associated with preserved mitochondrial function and to an increased survival of nerve cells in vitro and in vivo in a variety of experimental models of cell insult. The biological and structural features of neuroglobin and the mitochondria-related mechanisms of neuroglobin-induced neuroprotection will be here briefly discussed. In this respect, the inhibition of the intrinsic pathway of apoptosis emerges as a key neuroprotective effect induced by the protein. These findings could open the possibility to develop efficient neuroglobin-mediated therapeutic strategies aimed at minimizing the neuronal cell death occurring in impacting neurological pathologies like stroke and neurodegenerative diseases.
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DOI：
10.1073/pnas.0905433106
发表时间：
2009-11-10
影响因子：
11.1
作者：
Abbruzzetti, Stefania;Faggiano, Serena;Viappiani, Cristiano
通讯作者：
Viappiani, Cristiano
影响因子：
3.9
作者：
Fago, Angela;Mathews, Antony J.;Brittain, Thomas
通讯作者：
Brittain, Thomas
影响因子：
4.4
作者：
Chan, Anita S. Y.;Saraswathy, Sindhu;Rao, Narsing A.
通讯作者：
Rao, Narsing A.
影响因子：
5.6
作者：
Brittain T;Skommer J;Raychaudhuri S;Birch N
通讯作者：
Birch N
影响因子：
4.6
作者：
Fago, A;Hundahl, C;Weber, RE
通讯作者：
Weber, RE