Incidence of Stroke in Europe at the Beginning of the 21st Century The European Registers of Stroke (EROS) Investigators
Incidence of Stroke in Europe at the Beginning of the 21st Century The European Registers of Stroke (EROS) Investigators
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DOI：
10.1161/strokeaha.108.535088
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发表时间：
2009-05-01
期刊：
影响因子：
8.3
通讯作者：
Wolfe, Charles D. A.
中科院分区：
文献类型：
--
作者：
Heuschmann, Peter U.;Di Carlo, Antonio;Wolfe, Charles D. A.
背景和目的--欧洲国家间卒中发病率的可比数据缺乏，因为以前的研究采用了不同的病例确定方法、不同的观察期和不同的年龄限制。（塞斯托-菲奥伦蒂诺）、立陶宛（考纳斯）、联合王国（伦敦）、西班牙（梅诺卡岛）和波兰（华沙）。在这些登记册中使用了标准化的标准，包括重叠的通知来源。总的来说，观察到的源人口为1 087 048人，从塞斯托菲奥伦蒂诺的47 236人到考纳斯的365 191人不等。纳入了来源人群中所有年龄组的所有首次卒中患者。数据收集在2004年至2006年期间进行; 4家中心收集了24个月的数据，2家收集了12个月的数据。粗年发病率进行了年龄调整，以欧洲population.Results-A共2129例首次中风患者登记。中位年龄为73岁，51%为女性。与平均发病率相比，根据欧洲人群调整后的年卒中发病率，男性在考纳斯较高，而在塞斯托-菲奥伦蒂诺和梅诺卡较低，女性在考纳斯和华沙较高，而在塞斯托-菲奥伦蒂诺和梅诺卡较低。男性总卒中发病率范围为101.2/100 000（95% CI，82.5 - 123.0）在Sesto Fiorentino中为239.3/100 000（95% CI，209.9 - 271.6），在考纳斯和女性中为63.0/100 000（95% CI，48.5 - 80.7），考纳斯为158.7/100 000（95% CI，135.0 - 185.4）。在华沙和考纳斯（分别为76%和67%）高血压患病率最高，梅诺卡岛和塞斯托菲奥伦蒂诺（分别为54%和62%），在我们的研究中，欧洲人群中风的风险在男性和女性之间的差异超过2倍。平均而言，东欧国家的中风发病率较高，南欧国家的发病率较低。（中风。2009; 40：1557-1563.）
Background and Purpose-Comparable data on stroke incidence across European countries are lacking because previous studies have used different methods of case ascertainment, different periods of observation, and different age restrictions.Methods-Population-based stroke registers were established in 6 European countries: France (Dijon); Italy (Sesto Fiorentino); Lithuania (Kaunas); the United Kingdom (London); Spain (Menorca); and Poland (Warsaw). Standardized criteria were used among these register including overlapping sources of notification. Overall, a source population of 1 087 048 inhabitants was observed, ranging from 47 236 in Sesto Fiorentino to 365 191 in Kaunas. All patients with first-ever stroke of all age groups from the source populations were included. Data collection took part between 2004 and 2006; 4 centers collected data for a 24-month and 2 for a 12-month time period. Crude annual incidence rates were age-adjusted to the European population.Results-A total of 2129 patients with first stroke were registered. Median age was 73 years and 51% were female. Annual stroke incidence adjusted to the European population was found in men to be higher in Kaunas and lower in Sesto Fiorentino and Menorca and in women to be higher in Kaunas and Warsaw and lower in Sesto Fiorentino and Menorca compared with mean incidence rates. Total stroke incidence ranged in men from 101.2 per 100 000 (95% CI, 82.5 to 123.0) in Sesto Fiorentino to 239.3 per 100 000 (95% CI, 209.9 to 271.6) in Kaunas and in women from 63.0 per 100 000 (95% CI, 48.5 to 80.7) in Sesto Fiorentino to 158.7 per 100 000 (95% CI, 135.0 to 185.4) in Kaunas. Differences in prior-to-stroke risk factors were found among the populations with prevalence of hypertension highest in Warsaw and Kaunas (76% and 67%, respectively) and lowest in Menorca and Sesto Fiorentino (54% and 62%, respectively).Conclusions-The risk of stroke among European populations in our study varied more than 2-fold in men and women. On average, higher rates of stroke were observed in eastern and lower rates in southern European countries. (Stroke. 2009; 40: 1557-1563.)