Cytosporacin, a highly unsaturated polyketide: Application of the ACCORD-ADEQUATE experiment to the structural determination of natural products
Cytosporacin, a highly unsaturated polyketide: Application of the ACCORD-ADEQUATE experiment to the structural determination of natural products
复制标题
DOI：
10.1021/jo030067f
复制
发表时间：
2003-08-08
影响因子：
3.6
通讯作者：
Carter, GT
中科院分区：
文献类型：
--
作者：
He, HY;Janso, JE;Carter, GT
Cytosporacin (1), a novel antibacterial polyketide containing naphthopyranone and isochromandione moieties, was isolated from the fermentation broth of the fungus Cytospora rhizophorae. A H-1-detected ACCORD-ADEQUATE pulse sequence that distinguished (2)J(CH) from (3)J(CH) correlations provided critical information for structural determination. NOE studies established the relative configuration and revealed the presence of two rotamers. A biosynthetic C-13-labeling experiment indicated that cytosporacin was derived from acetate origin.
