Neuroprotective potential of dietary restriction against kainate-induced excitotoxicity in adult male Wistar rats
Neuroprotective potential of dietary restriction against kainate-induced excitotoxicity in adult male Wistar rats
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DOI：
10.1016/j.brainresbull.2005.07.015
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发表时间：
2005-11-30
影响因子：
3.8
通讯作者：
Kaur, G
中科院分区：
文献类型：
--
作者：
Sharma, S;Kaur, G
饮食因素对神经系统及其疾病易感性的影响是生物医学研究的一个活跃领域。最近的研究表明，饮食限制（DR）可以对大脑功能以及对损伤和疾病的脆弱性产生深远的影响，还可以增强突触可塑性，这可能会增加大脑抵抗衰老和恢复损伤后功能的能力。在我们的研究中，服用红藻氨酸后，海马 CA3 区域的神经元细胞死亡显着减少，表明饮食限制可能会产生神经保护作用。我们研究了 3 个月的 DR（隔日喂养方案）对红藻氨酸诱导的成年雄性 Wistar 大鼠兴奋性毒性后不同脑区（如大脑半球、间脑、小脑和脑干）抗氧化剂和抗氧化酶的影响。本研究报告了饮食限制对不同抗氧化剂和抗氧化酶对年轻成年雄性 Wistar 大鼠不同脑区红藻氨酸诱导的兴奋性毒性的有益影响。在同一组实验条件下，还研究了大鼠大脑离散区域的应激反应蛋白热休克蛋白 70 (HSP 70) 的表达。 DR 显着增强红藻氨酸 (KA) 治疗大鼠中 HSP 70 的表达，而 KA 治疗随意喂养的大鼠则导致 HSP 70 表达降低。观察到 DR 通过增强红藻氨酸处理的大鼠中 HSP 70 的表达来发挥神经保护作用。 (c) 2005 Elsevier Inc. 保留所有权利。
The influence that dietary factors have on the nervous system and its susceptibility to disease, is an active area of biomedical research. Recent studies have shown that dietary restriction (DR) can have profound effect on brain function and vulnerability to injury and disease and can also enhance synaptic plasticity, which may increase the ability of brain to resist aging and restore function following injury. The dietary restriction may result in neuroprotection as suggested by marked reduction in neuronal cell death of the CA3 region of hippocampus after kainate administration in our study. We examined the effects of 3 months of DR (alternate day feeding regimen) on the antioxidants and antioxidant enzymes from different brain regions such as cerebral hemispheres, diencephalon, cerebellum and brain stem after kainate-induced excitotoxicity in adult male Wistar rats. The present study reports the beneficial effects of dietary restriction on different antioxidants and antioxidant enzymes against kainate-induced excitotoxicity in different brain regions of young adult male Wistar rats. The expression of stress response protein heat shock protein 70 (HSP 70) was also studied from discrete regions of rat brain under the same set of experimental conditions. DR significantly enhanced the expression of HSP 70 in kainic acid (KA)-treated rats, whereas KA treatment of ad libitum fed rats resulted in decreased HSP 70 expression. The DR was observed to exert neuroprotection by enhancing the expression of HSP 70 in kainic acid treated rats. (c) 2005 Elsevier Inc. All rights reserved.