Fetal growth velocity: Kinetic, clinical, and biological aspects
Fetal growth velocity: Kinetic, clinical, and biological aspects
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DOI：
10.1136/fn.74.1.f10
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发表时间：
1996-01-01
影响因子：
4.4
通讯作者：
Milani, S
中科院分区：
文献类型：
--
作者：
Bertino, E;DiBattista, E;Milani, S
为了确定胎儿生长动力学，分析了在围产期生长调查框架内纵向收集的产前数据。样本包括238例单胎正常妊娠，选择在热那亚和都灵（1987年至1990年），并通过超声扫描反复评估（每次妊娠5至9次）。考虑了五个形态测量性状：BPD生长速率在孕中期的早期似乎增加，随后下降：头径和围（约18周）比股骨长（20周）和腹围（22周）更陡峭和更早。使用纵向两阶段线性模型追踪速度标准：这确保了对生长曲线形状的无偏描述，即使生长动力学是异步的，以及对外部百分位数的有效估计-这对于诊断目的最有用。
With the aim of determining fetal growth kinetics, prenatal data were analysed which had been longitudinally collected in the framework of a perinatal growth survey. The sample comprised 238 singleton normal pregnancies, selected in Genoa and Turin (between 1987 and 1990), and repeatedly assessed by ultrasound scans (five to nine per pregnancy). Five morphometric traits were considered: BPD (biparietal diameter), HC (head circumference), FDL (femur diaphysis length) and AC (abdomen circumference).Growth rate seemed to increase in the early part of the second trimester, and decrease subsequently: velocity peaks were steeper and earlier for head diameters and circumference (about 18 weeks) than for femur length (20 weeks) and abdomen circumference (22 weeks). Velocity standards were traced using a longitudinal two-stage linear model: this ensures unbiased description of the shape of the growth curve, even when growth kinetics are asynchronous, and efficient estimation of the outer centiles - the most useful for diagnostic purposes.