Iodide-Mediated Rapid and Sensitive Surface Etching of Gold Nanostars for Biosensing
Iodide-Mediated Rapid and Sensitive Surface Etching of Gold Nanostars for Biosensing
复制标题
用于生物传感的金纳米星的碘化物介导快速灵敏表面蚀刻
DOI：
10.1002/ange.202017317
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发表时间：
2021
影响因子：
--
通讯作者：
Xianyu Y
中科院分区：
文献类型：
--
作者：
Xianyu Y
碘化物介导的表面蚀刻可以通过以快速和灵敏的方式蚀刻纳米颗粒突起的高能面来定制金纳米星的表面等离子体共振。通过探索这种蚀刻的基本机制和影响它的关键参数（如碘化物，氧气，pH值和温度），我们显示了它在灵敏的生物传感系统中的潜力。辣根过氧化物酶催化的碘化物氧化能够控制金纳米星蚀刻成球形金纳米颗粒，其中表面等离子体共振中产生的光谱偏移产生溶液的明显颜色变化。我们进一步将这种酶调节的金纳米星表面蚀刻发展成用于等离子体免疫测定的多功能平台，其中通过磁珠和点击化学的信号放大可以实现高灵敏度。
Iodide‐mediated surface etching can tailor the surface plasmon resonance of gold nanostars through etching of the high‐energy facets of the nanoparticle protrusions in a rapid and sensitive way. By exploring the underlying mechanisms of this etching and the key parameters influencing it (such as iodide, oxygen, pH, and temperature), we show its potential in a sensitive biosensing system. Horseradish peroxidase‐catalyzed oxidation of iodide enables control of the etching of gold nanostars to spherical gold nanoparticles, where the resulting spectral shift in the surface plasmon resonance yields a distinct color change of the solution. We further develop this enzyme‐modulated surface etching of gold nanostars into a versatile platform for plasmonic immunoassays, where a high sensitivity is possible by signal amplification via magnetic beads and click chemistry.