LESIONS OF FRONTAL-CORTEX DIMINISH THE AUDITORY MISMATCH NEGATIVITY
LESIONS OF FRONTAL-CORTEX DIMINISH THE AUDITORY MISMATCH NEGATIVITY
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DOI：
10.1016/0013-4694(94)00173-1
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发表时间：
1994-11-01
期刊：
影响因子：
--
通讯作者：
NAATANEN, R
中科院分区：
文献类型：
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作者：
ALHO, K;WOODS, DL;NAATANEN, R
当背外侧前额叶皮层（DPFCx）损伤的患者和年龄匹配的对照受试者执行视觉反应时间任务时，记录了对无人参与的听觉刺激的事件相关脑电位。听觉刺激由重复的标准音调（1000 Hz）的单声道序列和偶尔出现的较高频率的异常音调（1300 Hz）组成。与对照组相比，DPFCx 患者表现出 P1 振幅增强（平均峰值潜伏期 50 毫秒），这与听觉皮层感觉输入的额介导门控减少一致。 DPFCk 患者在较宽的潜伏期范围（130-210 毫秒）内，异常音调引起的失配负性 (MMN) 有所减少，尤其是在病变半球上以及传递到病变同侧耳朵的音调。结果表明，DPFCx 和 DPFCx 时间预测在无意识听觉刺激序列中的物理变化定向中发挥着关键作用。
Event-related brain potentials to non-attended auditory stimuli were recorded from patients with dorsolateral prefrontal cortex (DPFCx) lesions and from age-matched control subjects as they performed a visual reaction time task. Auditory stimuli consisted of monaural sequences of repetitive standard tones (1000 Hz) and occasional deviant tones of a higher frequency (1300 Hz). In comparison with control subjects, DPFCx patients showed enhanced P1 amplitudes (mean peak latency 50 msec), consistent with reduced frontally mediated gating of sensory input to the auditory cortex. The mismatch negativity (MMN) elicited by deviant tones was reduced in DPFCk patients over a broad latency range (130-210 msec), especially over the lesioned hemisphere and for tones delivered to the ear ipsilateral to the lesion. The results suggest that DPFCx and DPFCx-temporal projections play a critical role in involuntary orienting to physical changes in sequences of nan-attended auditory stimuli.