High-risk human papillomavirus cervical infections among healthy women in Guadeloupe.
High-risk human papillomavirus cervical infections among healthy women in Guadeloupe.
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瓜德罗普（Guadeloupe）健康妇女中的高风险人乳头瘤病毒宫颈病毒感染。
DOI：
10.1016/j.ijid.2015.10.012
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Janky E
中科院分区：
文献类型：
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作者：
Cordel N;Ragin C;Trival M;Tressières B;Janky E
评估法属西印度群岛瓜德罗普岛健康妇女宫颈高危人乳头瘤病毒（HR HPV）感染及其类型分布。回顾性记录2013年1月1日至2014年12月31日在本岛最大病理实验室连续接受宫颈癌筛查并进行HPV基因分型的非妊娠妇女的详细资料。所有具有HPV基因分型结果的女性都被纳入研究。收集了618名女性（中位年龄42岁）的HR HPV基因分型结果。HR HPV宫颈感染的总体患病率为36.1%(95%可信区间（CI） 32.3-40.0%)，其类型分布如下：HPV 16或18与其他HPV类型无关，7.3% (95% CI 5.4-9.6%)；其他HR HPV类型，不包括HPV 16或18,28.8% （95% CI 25.3-32.5%）。随着细胞学等级的严重程度，整体HR HPV和16或18以外的HR HPV感染的患病率显著增加（p < 0.001），从正常细胞学的19.7%到不确定意义的非典型鳞状细胞（ASC-US）的53.8%和低级别鳞状上皮内病变（LSIL）的67.7%。在瓜德罗普岛，不论年龄和细胞学等级，除16和18基因型外的HR HPV宫颈感染的高流行率表明，在这个加勒比国家，新的九价HPV疫苗预防HPV感染相关癌症的潜在益处。
To assess high-risk human papillomavirus (HR HPV) cervical infections and their type distribution among healthy women in Guadeloupe, French West Indies. The details of consecutive non-pregnant women who attended cervical cancer screening and had HPV genotyping performed at the largest pathology laboratory on the island from January 1, 2013 to December 31, 2014 were recorded retrospectively. All women with available HPV genotyping results were included in the study. HR HPV genotyping results for 618 women (median age 42 years) were collected. The overall prevalence rate of HR HPV cervical infection was 36.1% (95% confidence interval (CI) 32.3–40.0%), with the following type distribution: HPV 16 or 18 irrespective of other HPV types, 7.3% (95% CI 5.4–9.6%); other HR HPV types excluding HPV 16 or 18, 28.8% (95% CI 25.3–32.5%). The prevalence rates of overall HR HPV and HR HPV other than 16 or 18 infection increased significantly (p < 0.001) with the severity of cytology grade, from 19.7% for normal cytology to 53.8% in atypical squamous cells of undetermined significance (ASC-US) and 67.7% in low-grade squamous intraepithelial lesions (LSIL). The high prevalence rate of HR HPV cervical infection with genotypes other than 16 and 18 in Guadeloupe, irrespective of age and the cytology grade, suggests a potential benefit of the new nine-valent HPV vaccine to prevent HPV infection-related cancers in this Caribbean country.