Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons
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DOI：
10.1016/s0166-4328(99)00041-8
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发表时间：
1999-09-01
影响因子：
2.7
通讯作者：
Robinson, TE
中科院分区：
文献类型：
--
作者：
Badiani, A;Oates, MM;Robinson, TE
我们先前曾报道，暴露于环境新颖性可以增强苯丙胺的行为激活作用及其在纹状体和其他大脑区域中诱导早期基因C-SAS的能力。在本研究中，我们使用双重原位杂交组织化学研究了苯丙胺和/或新颖性对两个纹状体神经元群体中C-FOS表达的影响，这些纹状体神经元优先表达DI或D2多巴胺受体mRNA。当腹膜内腹膜内的家用笼中的大鼠时，苯丙胺（2.0 mg/kg）仅在D1神经元中增加C-FOS表达。相反，当在新的环境中对大鼠施用相同剂量的苯丙胺时，在D1和D2神经元中，C-FOS都会增加。我们得出的结论是，苯丙胺参与的神经种群随着其管理的情况而变化。 （c）1999 Elsevier Science B.V.保留所有权利。
We have reported previously that exposure to environmental novelty enhances the behavioral activating effects of amphetamine and its ability to induce the immediate early gene c-Sas in the striatum and in other brain regions. In the present study, we used double in situ hybridization histochemistry to study the effect of amphetamine and/or novelty on c-fos expression in two populations of striatal neurons that preferentially express either DI or D2 dopamine receptor mRNA. When given intraperitoneally to rats in their home cage, amphetamine (2.0 mg/kg) increased c-fos expression only in D1 neurons. In contrast, when the same dose of amphetamine was administered to rats in a novel environment, c-fos was increased in both D1 and D2 neurons. We conclude that the neural populations engaged by amphetamine vary as a function of the circumstances surrounding its administration. (C) 1999 Elsevier Science B.V. All rights reserved.