Right Ventricular Strain and Dyssynchrony Assessment in Arrhythmogenic Right Ventricular Cardiomyopathy Cardiac Magnetic Resonance Feature-Tracking Study
Right Ventricular Strain and Dyssynchrony Assessment in Arrhythmogenic Right Ventricular Cardiomyopathy Cardiac Magnetic Resonance Feature-Tracking Study
复制标题
DOI：
10.1161/circimaging.115.003647
复制
发表时间：
2015-11-01
影响因子：
7.5
通讯作者：
Nucifora, Gaetano
中科院分区：
文献类型：
--
作者：
Prati, Giulio;Vitrella, Giancarlo;Nucifora, Gaetano
背景由于右室收缩模式复杂，通过心脏磁共振（CMR）成像对致瘤性右室心肌病（ARVC）右室（RV）局部功能障碍的分析可能是不够的。本研究的目的是确定使用RV应变和不同步评估ARVC使用功能跟踪CMR analysis.Methods和结果32个连续的ARVC患者被称为CMR成像。32例特发性RV流出道心律失常患者和32例年龄和性别与ARVC组匹配的对照受试者被纳入进行比较。进行CMR成像以评估双心室功能;对电影CMR图像进行特征跟踪分析，以评估区域和整体纵向、周向和径向RV应变以及RV不同步性（定义为RV节段达到峰值应变时间的SD）。RV全局纵向应变（-175% vs-26 +/- 6% vs-29 +/- 6%; P-23.2%，RV纵向应变达峰时间SD>113.1 ms，RV周向应变达峰时间SD>177.1 ms，正确识别率分别为88%，75%，63%的ARVC患者没有或只有轻微的CMR标准诊断ARVC。结论通过特征跟踪CMR进行应变分析有助于客观量化ARVC患者的整体和区域RV功能障碍和RV不同步，并提供了传统电影CMR成像的增量价值。
Background Analysis of right ventricular (RV) regional dysfunction by cardiac magnetic resonance (CMR) imaging in arrhythmogenic RV cardiomyopathy (ARVC) may be inadequate because of the complex contraction pattern of the RV. Aim of this study was to determine the use of RV strain and dyssynchrony assessment in ARVC using feature-tracking CMR analysis.Methods and Results Thirty-two consecutive patients with ARVC referred to CMR imaging were included. Thirty-two patients with idiopathic RV outflow tract arrhythmias and 32 control subjects, matched for age and sex to the ARVC group, were included for comparison purpose. CMR imaging was performed to assess biventricular function; feature-tracking analysis was applied to the cine CMR images to assess regional and global longitudinal, circumferential, and radial RV strains and RV dyssynchrony (defined as the SD of the time-to-peak strain of the RV segments). RV global longitudinal strain (-175% versus -26 +/- 6% versus -29 +/- 6%; P-23.2%, SD of the time-to-peak RV longitudinal strain >113.1 ms, and SD of the time-to-peak RV circumferential strain >177.1 ms allowed correct identification of 88%, 75%, and 63% of ARVC patients with no or only minor CMR criteria for ARVC diagnosis.Conclusions Strain analysis by feature-tracking CMR helps to objectively quantify global and regional RV dysfunction and RV dyssynchrony in patients with ARVC and provides incremental value over conventional cine CMR imaging.