Low temperature plasma promotes the healing of chronic wounds in diabetic mice
Low temperature plasma promotes the healing of chronic wounds in diabetic mice
复制标题
低温等离子体促进糖尿病小鼠慢性伤口愈合
DOI：
10.1088/1361-6463/ab7514
复制
发表时间：
2020-04-29
影响因子：
3.4
通讯作者：
Chen, Hongxiang
中科院分区：
文献类型：
--
作者：
Pan, Shuhui;Zhang, Song;Chen, Hongxiang
A handheld low temperature plasma (LTP) device has been developed for safe and effective wound healing. The room temperature, long operating range plasma produced by this device was acceptable for the genetic diabetic db/db mice. Three working gas admixture ratios, helium only, helium +0.1% O2 and helium +1% O2, of the LTP device were compared on the wound healing efficiency. The LTP with the working gas of helium +0.1% O2, produced more RONS. Its higher concentration of ROS resulted in higher sterilization efficiency, which decreased the oxygen consumed by bacteria and increased the oxygen supply to extracellular matrix and growing blood vessels. Its higher concentration of NO stimulated keratinocytes to secret growth factors. Therefore, it realized faster chronic wound healing. The other working gases admixture ratio were also effective in the wound healing promotion in diabetic mice. Taken together, these results suggest that LTP can be used to promote healing in chronic diabetic wounds.
