Cell fusion in health and disease. Volume II: cell fusion in disease. Introduction.
Cell fusion in health and disease. Volume II: cell fusion in disease. Introduction.
复制标题
健康和疾病中的细胞融合。
DOI：
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发表时间：
2011
影响因子：
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通讯作者：
K. Zänker
中科院分区：
文献类型：
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作者：
T. Dittmar;K. Zänker
虽然细胞融合是生命中无所不在的过程，但迄今为止，对高等生物中这种生物现象所涉及的机制和分子知之甚少。健康与疾病的细胞融合第2卷涵盖了细胞融合的黑暗面：即它在病理生理过程中的作用。国际领先的专家将提出最新的概述有关细胞融合介导的水平基因转移的细菌和病毒，III类病毒膜融合蛋白，滋养层融合在三体21，和微泡在恶性肿瘤中的作用。特别关注的是癌症中的细胞融合，以及这种生物学现象如何启动（复发）癌症干细胞的起源以及驱动多发性骨髓瘤，结肠癌，乳腺癌和恶性黑色素瘤的进展。因此，健康与疾病中的细胞融合第2卷代表了研究人员，医生或有兴趣反映细胞融合黑暗面的专业人士的最先进的工作。
Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. Cell Fusion in Health and Disease Volume 2 is covering the dark side of cell fusion: namely its role in pathophysiological processes. International leading experts will present up-to-date overviews about cell fusion mediated horizontal gene transfer in bacteria and viruses, class III viral membrane fusion proteins, trophoblast fusion in trisomy 21, and the role of microvesicles in malignancies. Particular attention is paid on cell fusion in cancer and how this biological phenomenon may initiate the origin of (recurrence) cancer stem cells as well as drive the progression of multiple myeloma, colon cancer, breast cancer, and malignant melanoma. Thus, Cell Fusion in Health and Disease Volume 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in reflecting the dark side of cell fusion.