Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC).
Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC).
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DOI：
10.12688/wellcomeopenres.14716.1
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Howe, Laura D
中科院分区：
文献类型：
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作者：
Houtepen, Lotte C;Heron, Jon;Howe, Laura D
背景：暴露于不良童年经历（ACE）是晚年健康状况不佳的危险因素。在这里，我们描述的ACE变量测量的雅芳纵向研究的父母和孩子（ALSPAC）的研究，和一种方法，用于获得汇总措施和处理缺失的数据。 方法：于2017年9月检索ALSPAC数据目录（59 608个变量），以测量出生至18岁之间的逆境暴露。6140逆境问题，然后筛选符合我们的ACE定义和二分法的适用性。该筛选确定了10个“经典”ACE的541个问题（性虐待、身体虐待或情绪虐待、情绪忽视、父母滥用药物、父母精神病或自杀企图、父母之间的暴力、父母分居、欺凌和父母刑事定罪）和9个额外的儿童援助中心（父母与子女之间的联系、对邻里关系的满意度、对父母的社会支持、对子女的社会支持、父母一方的身体疾病、子女的身体疾病、经济困难、社会地位低下和子女与伴侣之间的暴力行为）。这些用于推导暴露于每种ACE的二元结构。最后，作为儿童期逆境的累积措施，19个ACE结构的不同组合进行了总结，得到总逆境分数。开发了一种适当的多重插补策略，以处理缺失数据的复杂模式。结果如下：出生至16岁期间暴露的ACE结构和ACE评分的患病率估计值与以前的报告相当（例如，4%的性虐待，18%的身体虐待，25%的欺凌，32%的父母分居）。结论：ACE结构，使用务实的方法来处理高维ALSPAC数据，可用于未来的分析在ALSPAC儿童的童年逆境。
Background: Exposure to adverse childhood experiences (ACEs) is a risk factor for poor later life health. Here, we describe the ACE variables measured in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC) study, and a method used to derive summary measures and deal with missing data in them. Methods: The ALSPAC data catalogue (59 608 variables) was searched in September 2017 for measures on adversity exposure between birth and 18 years. 6140adversity questions were then screened for conforming to our ACE definitions and suitability for dichotomisation. This screening identified 541 questions on ten 'classic' ACEs (sexual, physical or emotional abuse, emotional neglect, substance abuse by the parents, parental mental illness or suicide attempt, violence between parents, parental separation, bullying and parental criminal conviction) and nine additional ACEs (bond between parent and child, satisfaction with neighbourhood, social support for the parent, social support for the child, physical illness of a parent, physical illness of the child, financial difficulties, low social class and violence between child and partner). These were used to derive a binary construct for exposure to each ACE. Finally, as cumulative measures of childhood adversity, different combinations of the 19 ACE constructs were summed to give total adversity scores. An appropriate strategy for multiple imputation was developed to deal with the complex patterns of missing data. Results: The ACE constructs and ACE-scores for exposure between birth and 16 years had prevalence estimates that were comparable to previous reports (for instance 4% sexual abuse, 18% physical abuse, 25% bullied, 32% parental separation). Conclusions: ACE constructs, derived using a pragmatic approach to handle the high dimensional ALSPAC data, can be used in future analyses on childhood adversity in ALSPAC children.