Histological alterations induced by electrode implantation and electrical stimulation in the human brain: A review
Histological alterations induced by electrode implantation and electrical stimulation in the human brain: A review
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DOI：
10.1111/j.1525-1403.2007.00114.x
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发表时间：
2007-07-01
期刊：
影响因子：
2.8
通讯作者：
Nuttin, Bart
中科院分区：
文献类型：
--
作者：
Van Kuyck, Kris;Welkenhuysen, Marleen;Nuttin, Bart
目标.脑电刺激是一种治疗顽固性慢性疼痛和运动障碍的方法。然而，植入电极和电刺激可能会引起电极头端周围的组织学变化。我们的目的是审查人类大脑中受到电刺激的组织学变化。方法.我们追踪了26例尸检研究，其中19例接受了小脑刺激，37例接受了脑深部电刺激。电极植入和电刺激诱导部分病例在电极周围形成纤维鞘，丢失相当大的神经元和有限的胶质增生。仅在某些病例中存在肉眼可见的损伤，主要是由于在明确植入电极丝和刺激器之前的术后评价期间牵拉延长电缆所致。结论.脑电刺激在某些患者中引起组织学变化。根据动物脑电刺激研究，这些变化可能与每个相位的电荷和电荷密度（及其相互作用）有关。
Objectives. Electrical brain stimulation is used as a treatment for patients with intractable chronic pain and movement disorders. However, the implantation of electrodes and electrical stimulation may induce histological changes around the electrode tip. We aimed to review the histological changes in humans that were electrically stimulated in the brain. Methods. We traced 26 autopsy studies of which 19 patients received cerebellar stimulation and 37 patients deep brain stimulation.Results. Electrode implantation and electrical stimulation induced in part of the cases formation of a fibrous sheath around the electrode, loss of fairly large neurons, and limited gliosis. Macroscopic lesions were present in only some cases, mostly due to pulling at the extension cable in the postoperative evaluation period preceding definite implantation of the electrode wire and stimulator. Conclusions. Electrical brain stimulation induces histological changes in some patients. According to electrical brain stimulation studies in animals, these changes can be related to the charge and charge density per phase (and their interaction).