Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender
Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender
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DOI：
10.1038/s41467-017-02648-0
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发表时间：
2018
影响因子：
16.6
通讯作者：
Xiao-Hong Xu
中科院分区：
文献类型：
--
作者：
Yi-Chao Wei;Shao-Ran Wang;Zhuo-Lei Jiao;Wen Zhang;Jun-Kai Lin;Xing-Yu Li;Shuai-Shuai Li;Xin Zhang;Xiao-Hong Xu
The medial preoptic area (mPOA) differs between males and females in nearly all species.examined to date, including humans. Here, using fiber photometry recordings of Ca2+ transients.in freely behaving mice, we show ramping activities in the mPOA that precede and.correlate with sexually dimorphic display of male-typical mounting and female-typical pup.retrieval. Strikingly, optogenetic stimulation of the mPOA elicits similar display of mounting.and pup retrieval in both males and females. Furthermore, by means of recording, ablation,.optogenetic activation, and inhibition, we show mPOA neurons expressing estrogen receptor.alpha (Esr1) are essential for the sexually biased display of these behaviors. Together, these.results underscore the shared layout of the brain that can mediate sex-specific behaviors in.both male and female mice and provide an important functional frame to decode neural.mechanisms governing sexually dimorphic behaviors in the future.
