A Method for the Measurement of Ionized Magnesium
A Method for the Measurement of Ionized Magnesium
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离子镁的测量方法
DOI：
10.1093/labmed/26.1.70
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
A. Okorodudu
中科院分区：
文献类型：
--
作者：
D. Filos;A. Okorodudu
离子化镁（Mg++）在生物过程中的作用最近才受到实验关注，尚未明确定义。已经报道了开发对镁敏感的离子选择性电极（ISE）的几种努力，并且使用涉及丙二酰胺亚基的基于离子载体的选择性电极已经取得了重大进展。我们在AVL 988-4 Na/Mg/Ca/pH分析仪（AVL Scientific，Roswell，Ga）中评估了基于这些载体之一的镁伊势。我们研究了该分析仪在精密度、线性和相对准确度方面的性能。电极的精度非常好，在病理学显著范围内具有线性响应。由于缺乏参考方法和一级标准，Mg++测量的准确性难以评估。伊势将为评估Mg++在患者护理管理中的使用提供急需的技术。
The role of ionized magnesium (Mg++) in biological processes only recently has received experimental attention and is not yet clearly defined. Several efforts to develop ion-selective electrodes (ISEs) sensitive to magnesium have been reported, and significant progress has been achieved with the use of ionophore-based selective electrodes involving malondiamide subunits. We evaluated a magnesium ISE based on one of these carriers in the AVL 988-4 Na/Mg/Ca/pH analyzer (AVL Scientific, Roswell, Ga). We studied the performance of this analyzer in terms of precision, linearity, and relative accuracy. Precision of the electrode was excellent, with a linear response over the pathologically significant range. Accuracy of Mg++ measurement is difficult to assess because of the lack of a reference method and primary standards. The ISE will provide the much-needed technology for evaluating the use of Mg++ in patient care management.