Induction of plasminogen activator by estrogen in a human breast cancer cell line (MCF-7).
Induction of plasminogen activator by estrogen in a human breast cancer cell line (MCF-7).
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在人乳腺癌细胞系 (MCF-7) 中雌激素诱导纤溶酶原激活剂。
DOI：
10.1016/0006-291x(79)91181-1
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发表时间：
1979
影响因子：
3.1
通讯作者：
T. Jorgensen
中科院分区：
文献类型：
--
作者：
W. Butler;W. Kirkland;T. Jorgensen
人类乳腺癌细胞株(MCF-7)产生一种纤溶酶原激活剂。在这些细胞的生长既不依赖也不受10−雌二醇刺激的条件下，10M雌二醇刺激纤溶酶原激活剂的产生。这种刺激被放线菌素D或放线菌亚胺阻止，这表明它可能需要新的RNA和蛋白质合成。刺激也被抗雌激素他莫昔芬抑制，但这种抑制可以被更高水平的雌二醇所克服。
The human breast cancer cell line (MCF-7) produces a plasminogen activator. Under conditions where the growth of these cells is neither dependent on nor stimulated by estradiol as little as 10−10M estradiol stimulates plasminogen activator production. This stimulation is prevented by actinomycin D or cycloheximide, indicating that it probably requires new RNA and protein synthesis. Stimulation is also inhibited by the antiestrogen tamoxifen but this inhibition can be overcome by higher levels of estradiol.