The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis.
The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis.
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DOI：
10.3390/cancers3010267
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发表时间：
2011-01-11
期刊：
影响因子：
5.2
通讯作者：
Maraveyas A
中科院分区：
文献类型：
--
作者：
Echrish H;Madden LA;Greenman J;Maraveyas A
在大多数晚期胰腺癌患者中发现了凝血异常的实验室证据，其临床后果是血管血栓栓塞症事件的高发生率和盛行率。其他后遗症被认为是定义恶性表型的机制的促进和加速，如侵袭、运输和锚定，建立转移的生态位和诱导血管生成。我们回顾了体外和临床前的证据，支持凝血器在胰腺癌转移过程中的作用，特别强调这一途径与临床靶向的生长因子受体途径的相互作用。止血、血管生成和表皮生长因子通路之间的联系及其作为治疗靶点的意义被考虑。
Laboratory evidence of aberrant coagulation is found in the majority of patients with advanced pancreatic cancer and a clinical consequence of this is the high incidence and prevalence of vascular thromboembolic events. Other sequelae are hypothesized to be the facilitation and acceleration of mechanisms that define the malignant phenotype, such as invasion, trafficking and anchoring, establishing the metastatic niche and inducing angiogenesis. We review the in vitro and preclinical evidence that supports the role of the coagulation apparatus in the metastatic process of pancreatic cancer, with a particular emphasis on interaction of this pathway with clinically-targeted growth factor receptor pathways. Links between hemostasis, angiogenesis and epidermal growth factor pathways and their significance as therapeutic targets are considered.