Communication between Cells of Different Type
Communication between Cells of Different Type
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不同类型细胞之间的通讯
作者：
W. Michalke;W. Loewenstein
许多类型的细胞都有组织严密的膜连接，使得分子可以从一个细胞的内部传递到另一个细胞，而几乎不流失到外部。至少在某些情况下，大部分（如果不是全部的话）表面膜似乎能够进行这种组织，因为如果连接被破坏，细胞对在其他地方重新连接，系统可以在几秒钟或几分钟内完全通信。显然，膜必须经历深刻的结构变化，使以前不透水的表面区域变得高度透水。这意味着两个膜上的连接区域在空间上的紧密匹配。问题是这种匹配是否能在不同的膜之间实现。为了找出这个问题的答案，我们将来自不同器官和物种的培养细胞配对，测量细胞之间的电通信。
MANY types of cells have membrane junctions so organized as to allow the passage of molecules from the interior of one cell to another with little loss to the outside1–6. At least in some cases, a large part if not all of the surface membrane seems to be capable of this organization, for if the junction is broken and the cell pair rejoined at some other place, the system can become fully communicating within seconds or minutes7,8. Evidently the membranes must undergo profound structural changes in such a way that previously impermeable surface regions become highly permeable. This implies a close spatial matching of the joining regions on the two membranes. The question arises whether such matching can be effected between membranes that differ from each other. To find something out about this problem, we have paired cultured cells from different organs and species, measuring the communication between cells electrically.