Region specific gene expressions in the central nervous system of the ascidian embryo.
Region specific gene expressions in the central nervous system of the ascidian embryo.
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DOI：
10.1016/s0925-4773(02)00383-0
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发表时间：
2002-12-01
影响因子：
1.2
通讯作者：
Satou, Yutaka
中科院分区：
文献类型：
--
作者：
Imai, Kaoru S.;Satoh, Nori;Satou, Yutaka
脊椎动物的大脑在发育过程中被划分为前脑、中脑和后脑。成纤维细胞生长因子8 （FGF8）表达于中脑/后脑边界（MHB），是一种组织者分子。先前的研究表明，基底脊索动物或海鞘动物的大脑也至少被划分为前/中脑和后脑。为了更好地了解海鞘脑区域化，我们将Ciona Fgf8/17/18基因的表达与Otx、En和Pax2/5/8基因的表达进行比较。这些基因的表达模式与脊椎动物前脑、中脑、MHB和后脑的表达模式相似，每个结构域的特征都是单独或联合表达Otx、Pax2/5/8、En和Fgf8/17/18。此外，假定的前脑和中脑分别表达Ci-FgfL和Ci-Fgf9/16/20。因此，Fgf基因的表达也标志着海鞘幼虫中枢神经系统的区域化。
The vertebrate brain is regionalized during development into forebrain, midbrain and hindbrain. Fibroblast growth factor 8 (FGF8) is expressed in the midbrain/hindbrain boundary (MHB) and functions as an organizer molecule. Previous studies demonstrated that the brain of basal chordates or ascidians is also regionalized at least into fore/midbrain and hindbrain. To better understand the ascidian brain regionalization, the expression of the Ciona Fgf8/17/18 gene was compared with the expression of Otx, En and Pax2/5/8 genes. The expression pattern of these genes resembled that of the genes in the vertebrate forebrain, midbrain, MHB and hindbrain, each of those domains being characterized by sole or combined expression of Otx, Pax2/5/8, En and Fgf8/17/18. In addition, the putative forebrain and midbrain expressed Ci-FgfL and Ci-Fgf9/16/20, respectively. Therefore, the regionalization of the ascidian larval central nervous system was also marked by the expression of Fgf genes.