Molecular mechanisms of cellular quiescence in apicomplexan parasites.
Molecular mechanisms of cellular quiescence in apicomplexan parasites.
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DOI：
10.1016/j.mib.2022.102223
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发表时间：
2022-10
影响因子：
5.4
通讯作者：
Caroline D. Keroack;M. Duraisingh
中科院分区：
文献类型：
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作者：
Caroline D. Keroack;M. Duraisingh
在顶复合体寄生虫中，静默是几种现象的基础。静止机制是多种多样的，其特征在模式生物中是保守的。系统方法可以识别静止的标记物和介质。静止是一种可逆的非增殖细胞状态，允许生物体在不利条件下持续存在。静息可由多种外部或内在因素引起。细胞通过一个协调的分子程序进入和退出静止状态，这是由信号、转录和翻译变化、表观遗传机制、代谢开关和细胞结构变化所控制的。这些机制已经在模式生物中得到了广泛的研究，越来越多的研究已经确定了顶复合体寄生虫的保守机制。在寄生虫感染的背景下，静止具有重要的临床影响：静止形式可能是治疗失败、复发感染和应激耐受性的基础。在这里，我们回顾了对顶复合体静止的最新认识，综合这些研究来突出保守的机制，并确定了有助于进一步表征静止的技术。了解顶复体静止的保守机制将为传播预防和根治感染提供途径。
HighlightsQuiescence underlies several phenomena in apicomplexan parasites.Mechanisms of quiescence are diverse, with features conserved with model organisms.Systems approaches can lead to identification of markers and mediators of quiescence.Quiescence is a reversible nonproliferative cellular state that allows organisms to persist through unfavorable conditions. Quiescence can be stimulated by a wide range of external or intrinsic factors. Cells undergo a coordinated molecular program to enter and exit from the quiescent state, which is governed by signaling, transcriptional and translational changes, epigenetic mechanisms, metabolic switches, and changes in cellular architecture. These mechanisms have been extensively studied in model organisms, and a growing number of studies have identified conserved mechanisms in apicomplexan parasites. Quiescence in the context of a parasitic infection has significant clinical impact: quiescent forms may underlie treatment failures, relapsing infections, and stress tolerance. Here, we review the latest understanding of quiescence in apicomplexa, synthesizing these studies to highlight conserved mechanisms, and identifying technologies to assist in further characterization of quiescence. Understanding conserved mechanisms of quiescence in apicomplexans will provide avenues for transmission prevention and radical cure of infections.