Regional myocardial radiotracer kinetics in dogs using miniature radiation detectors.
Regional myocardial radiotracer kinetics in dogs using miniature radiation detectors.
复制标题
使用微型辐射探测器进行狗的局部心肌放射性示踪动力学。
DOI：
10.1152/ajpheart.1982.242.5.h849
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Pohost,GM
中科院分区：
文献类型：
--
作者：
Jacobs,ML;Okada,RD;Daggett,WM;Fowler,BN;Strauss,HW;Geffin,G;Pohost,GM
设计并验证了一种可植入的连续测量局部心肌放射性同位素活度的装置。探针由一个2毫米3的碲化镉晶体组成，周围包裹着铅箔，放置在外径4.5毫米的钢瓶中。这种微型伽马探测器测量的铊-201系列稀释度的活度与井计数器测量的活度相关良好（r = 0.99）。将犬模型局部心肌铊-201活性的体内探针测量值与穿孔活检的活性进行比较，同样具有良好的相关性（r = 0.90）。晶体安装在改良的动脉钳上，通过心尖插入左心室，位于前壁或后壁的心内膜表面。因此，不需要过多的血池和对面心脏壁的背景就可以测量区域同位素活动。该探针被发现最适合于监测能量在60至250 keV之间的同位素的活动。有了一对这样的装置，在正常和缺血心肌中对放射性同位素如铊-201的心肌动力学进行动态研究现在是可能的。
An implantable device for continuous measurement of regional myocardial radioisotope activity was designed and validated. The probe consists of a 2-mm3 cadmium telluride crystal surrounded by lead foil housed in a 4.5-mm outer diameter steel cylinder. Activity in serial dilutions of thallium-201 measured by this miniature gamma detector correlated well with activity measured in the well counter (r = 0.99). In vivo probe measurements of regional myocardial thallium-201 activity in a canine model were compared with activity in punch biopsies, again with excellent correlation (r = 0.90). The crystal was mounted on a modified arterial clamp, which was inserted into the left ventricle through, the apex and situated on the endocardial surface of the anterior or posterior wall. It was thus possible to measure regional isotope activity without excessive background from the blood pool and opposite heart wall. The probe was found best suited for monitoring activities of isotopes with energies between 60 and 250 keV. With a pair of these devices, dynamic studies of the myocardial kinetics of radioisotopes such as thallium-201 in normal and ischemic myocardium are now possible.