The Role of Pulsed Electromagnetic Fields on the Radical Pair Mechanism
The Role of Pulsed Electromagnetic Fields on the Radical Pair Mechanism
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DOI：
10.1002/bem.22358
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发表时间：
2021-07-05
影响因子：
1.9
通讯作者：
Martino, Carlos F.
中科院分区：
文献类型：
--
作者：
Castello, Pablo;Jimenez, Pablo;Martino, Carlos F.
近几十年来，脉冲电磁场（PEMF）在治疗学中的应用已成为生物电磁学领域的主要研究领域之一。然而，由于对相互作用的生物物理机制缺乏共识，这一领域的进展受到阻碍，这种机制无法令人满意地解释低水平、非热电磁场如何能够充分影响化学，从而在活生物体中引起生物效应。这特别适用于感应电场太小而不能产生任何后果的生物反应的情况。越来越多的实验观察可以解释这些效应的本质，有力地说明了一种被称为自由基对机制（RPM）的理论的参与。这一机制解释了一对具有不同化学命运的活性氧如何通过塞曼和超精细相互作用受到低强度外磁场的影响。到目前为止，还没有研究在RPM背景下复杂时空信号的影响。在这里，我们通过使用一个通用的PEMF测试信号和不同复杂性的RPM模型，对这种效应进行了计算研究。令人惊讶的是，我们的研究结果表明，根据PEMF测试信号的特定方向，相对于背景静态磁场、其波形和两者的振幅，在不同的范围内，可以获得截然不同的化学结果。这些结果为解释质子交换电场信号在自由基对化学反应中的独特生物学相关性提供了基础。(c) 2021年生物电磁学学会。
In recent decades, the use of pulsed electromagnetic fields (PEMF) in therapeutics has been one of the main fields of activity in the bioelectromagnetics arena. Nevertheless, progress in this area has been hindered by the lack of consensus on a biophysical mechanism of interaction that can satisfactorily explain how low-level, non-thermal electromagnetic fields would be able to sufficiently affect chemistry as to elicit biological effects in living organisms. This specifically applies in cases where the induced electric fields are too small to generate a biological response of any consequence. A growing body of experimental observations that would explain the nature of these effects speaks strongly about the involvement of a theory known as the radical pair mechanism (RPM). This mechanism explains how a pair of reactive oxygen species with distinct chemical fate can be influenced by a low-level external magnetic field through Zeeman and hyperfine interactions. So far, a study of the effects of complex spatiotemporal signals within the context of the RPM has not been performed. Here, we present a computational investigation of such effects by utilizing a generic PEMF test signal and RPM models of different complexity. Surprisingly, our results show how substantially different chemical results can be obtained within ranges that depend on the specific orientation of the PEMF test signal with respect to the background static magnetic field, its waveform, and both of their amplitudes. These results provide a basis for explaining the distinctive biological relevance of PEMF signals on radical pair chemical reactions. (c) 2021 Bioelectromagnetics Society.