Remembering our past: Functional neuroanatomy of recollection of recent and very remote personal events
Remembering our past: Functional neuroanatomy of recollection of recent and very remote personal events
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DOI：
10.1093/cercor/bhh082
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发表时间：
2004-11-01
期刊：
影响因子：
3.7
通讯作者：
Moscovitch, M
中科院分区：
文献类型：
--
作者：
Gilboa, A;Winocur, G;Moscovitch, M
功能性磁共振成像被用来研究与几十年前的记忆提取有关的大脑区域。为了探索自传体记忆，家庭照片是在没有参与者参与的情况下由同伴选择的，从而消除了许多可能混淆以前神经成像研究的变量。我们发现，上下文丰富的记忆与语言和楔前叶脑回的活动独立于他们的年龄。相比之下，压后皮层对最近发生的事件更活跃，无论记忆的生动性如何。海马的激活与再体验的丰富性（生动性）有关，而不是记忆本身的年龄。远程记忆与分布激活沿着的头尾轴的海马体，而激活与最近的记忆聚集在前部。这也许可以解释为什么海马体的局限性损伤不成比例地影响最近的记忆。这些发现与长期记忆巩固的理论不一致，并且更容易被多痕迹理论所接受，该理论认为详细的记忆总是依赖于海马体。
Functional magnetic resonance imaging was used to study brain regions implicated in retrieval of memories that are decades old. To probe autobiographical memory, family photographs were selected by confederates without the participant's involvement, thereby eliminating many of the variables that potentially confounded previous neuroimaging studies. We found that context-rich memories were associated with activity in lingual and precuneus gyri independently of their age. By contrast, retrosplenial cortex was more active for recent events regardless of memory vividness. Hippocampal activation was related to the richness of re-experiencing (vividness) rather than the age of the memory per se. Remote memories were associated with distributed activation along the rostrocaudal axis of the hippocampus whereas activation associated with recent memories was clustered in the anterior portion. This may explain why circumscribed lesions to the hippocampus disproportionately affect recent memories. These findings are incompatible with theories of long-term memory consolidation, and are more easily accommodated by multiple-trace theory, which posits that detailed memories are always dependent on the hippocampus.