Electrical stimulation of the anterior ethmoidal nerve produces the diving response
Electrical stimulation of the anterior ethmoidal nerve produces the diving response
复制标题
DOI：
10.1016/s0006-8993(99)01374-8
复制
发表时间：
1999-05-29
期刊：
影响因子：
2.9
通讯作者：
Panneton, WM
中科院分区：
文献类型：
--
作者：
McCulloch, PF;Faber, KM;Panneton, WM
刺激上呼吸道通常会引起呼吸暂停，但也会引起迷走神经介导的心动过缓和交感神经介导的外周血管阻力增加。这种心肺反应，通常称为潜水反应，通常由鼻刺激引发。目的：研究支配麝鼠鼻粘膜的筛前神经（AEN）。电刺激AEN（通常为50 Hz，100 μ s和500 μ A）产生立即和持续的心动过缓和呼吸停止类似的潜水反应。在5 s刺激期间，心率（HR）从264 +/- 18显著降低至121 +/- 8 bpm，同时伴有4.2 +/- 0.9 s呼吸暂停。血压从97.9 +/- 4.8降至91.2 +/- 6.4 mmHg。利用（1）WGA-HRP标记的AEN三叉神经节细胞的横截面积和（2）AEN的电子显微镜分析的估计，我们发现大约65%的AEN由无髓鞘C-纤维组成。此外，72.4%的来自支配鼻通道的神经的有髓纤维具有小直径（< 6 μ m，推测为A δ纤维）。因此，麝鼠的AEN含有高浓度的小直径纤维（89.8%）。结论：电刺激麝鼠AEN内的小直径纤维可产生类似于潜水反应的心血管和呼吸反应。(C)1999 Elsevier Science B. V.保留所有权利。
Stimulation of the upper respiratory tract usually produces apnea, but it can also produce a vagally mediated bradycardia and a sympathetically mediated increase in peripheral vascular resistance. This cardiorespiratory response, often called the diving response, is usually initiated by nasal stimulation. The purpose of this research was to investigate the anterior ethmoidal nerve (AEN) that innervates the nasal mucosa of muskrats (Ondatra zibethicus). Electrical stimulation of the AEN (typically 50 Hz, 100 mu s and 500 mu A) produced immediate and sustained bradycardia and cessation of respiration similar to that of the diving response. Heart rate (HR) significantly decreased from 264 +/- 18 to 121 +/- 8 bpm, with a concurrent 4.2 +/- 0.9 s apnea, during the 5 s stimulation period. BP decreased from 97.9 +/- 4.8 to 91.2 +/- 6.4 mmHg. Using estimations from (1) cross-sectional areas of AEN trigeminal ganglion cells labeled with WGA-HRP, and (2) electron microscopic analysis of the AEN, we found that approximately 65% of the AEN is composed of unmyelinated C-fibers. In addition, 72.4% of myelinated fibers from the nerves that innervate the nasal passages were of small diameter (< 6 mu m, presumably A delta fibers). Thus, the AEN of the muskrat contains a high concentration of small diameter fibers (89.8%). We conclude that electrical stimulation of small diameter fibers within the AEN of muskrats can produce the cardiovascular and respiratory responses similar to that of the diving response. (C) 1999 Elsevier Science B.V. All rights reserved.