Medial temporal lobe activity for recognition of recent and remote famous names: an event-related fMRI study
Medial temporal lobe activity for recognition of recent and remote famous names: an event-related fMRI study
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DOI：
10.1016/j.neuropsychologia.2004.09.005
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Rao, SA
中科院分区：
文献类型：
--
作者：
Douville, K;Woodard, JL;Rao, SA
先前检查著名面孔识别的神经影像学研究已经确定了广泛的双边神经网络的激活 [Gorno Tempini, M. L., Price, C. J., Josephs, O., Vandenberghe, R., Cappa, S. F., Kapur, N. 等人。 （1998）。维持面部和专有名称处理的神经系统。 Brain, 121, 2103-2118]，包括内侧颞叶 (MTL)，特别是海马复合体 [Haist, F., Bowden, G. J., & Mao, H. (2001)。功能性磁共振成像揭示了数十年来人类记忆的巩固。自然神经科学，4，1139-1145； Leveroni, C. L.、Seidenberg, M.、Mayer, A. R.、Mead, L. A.、Binder, J. R. 和 Rao, S. M. (2000)。神经系统，是识别熟悉的和新学到的面孔的基础。神经科学杂志，20, 878-886]。自传体、情景记忆检索中海马功能的一种模型认为，无论记忆的时间或年龄如何，海马复合体在检索任务中都保持活跃（多迹理论，MTT），而另一种建议认为海马复合体在自传体记忆的检索中发挥着有时限的作用。目前的事件相关功能磁共振成像研究主要关注 15 名右利手健康老年人（平均年龄 = 70 岁）的内侧颞叶及其对两个不同时代（1990 年代和 1950 年代）名人识别判断的反应。对年轻和年长受试者的独立样本进行的试点研究确保刺激代表最近和遥远的时期。与非著名名字相比，在识别近期和远古时期的熟悉名字时，观察到海马和海马旁回 (PHG) 双侧 MR 信号活动增加。然而，右侧海马体和右侧 PHG 的脉冲响应函数表现出对不同时期刺激的差异反应，其中 1990 年代的名称显示出最大的 MR 信号强度变化，其次是 1950 年代的名称，最后是箔。无论相对于箔片的时间历元如何，名人的识别都会产生显着的双边 MTL 激活，这一发现为 MTT 模型提供了支持。然而，在正确的 MTL 中发现时间梯度也为 HC 模型提供了支持，因为相对于遥远的著名名字，与最近著名的名字相关的 MTL 响应更大。 (c) 2004 Elsevier Ltd. 保留所有权利。
Previous neuromiaging studies examining recognition of famous faces have identified activation of an extensive bilateral neural network [Gorno Tempini, M. L., Price, C. J., Josephs, O., Vandenberghe, R., Cappa, S. F., Kapur, N. et al. (1998). The neural systems sustaining face and proper-name processing. Brain, 121, 2103-2118], including the medial temporal lobe (MTL) and specifically the hippocampal complex [Haist, F., Bowden, G. J., & Mao, H. (2001). Consolidation of human memory over decades revealed by functional magnetic resonance imaging. Nature Neuroscience, 4, 1139-1145; Leveroni, C. L., Seidenberg, M., Mayer, A. R., Mead, L. A., Binder, J. R., & Rao, S. M. (2000). Neural systems, underlying the recognition of familiar and newly learned faces. Journal of Neuroscience, 20, 878-886]. One model of hippocampal functioning in autobiographical, episodic memory retrieval argues that the hippocampal complex remains active in retrieval tasks regardless of time or age of memory (multiple trace theory, MTT), whereas another proposal posits that the hippocampal complex plays a time-limited role in retrieval of autobiographical memories. The current event-related fMRI study focused on the medial temporal lobe and its response to recognition judgments of famous names from two distinct time epochs (1990s and 1950s) in 15 right-handed healthy older adults (mean age = 70 years). A pilot study with an independent sample of young and older subjects ensured that the stimuli were representative of a recent and remote time period. Increased MR signal activity was observed on a bilateral basis for both the hippocampus and parahippocampal gyrus (PHG) during recognition of familiar names from both the recent and remote time periods when compared to non-famous names. However, the impulse response functions in the right hippocampus and right PHG demonstrated a differential response to stimuli from different time epochs, with the 1990s names showing the greatest MR signal intensity change, followed by the 1950s names, followed by foils. The finding that recognition of famous names produced significant bilateral MTL activation regardless of time epoch relative to foils provides support for the MTT model. However, the finding of a temporal gradient in the right MTL also provides support for the HC model, given the greater MTL response associated with recently famous names relative to remotely famous names. (c) 2004 Elsevier Ltd. All rights reserved.