Hypersensitivity and nanoparticles: update and research trends.
Hypersensitivity and nanoparticles: update and research trends.
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DOI：
10.15386/cjmed-574
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Orasan R
中科院分区：
文献类型：
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作者：
Mocan T;Matea CT;Iancu C;Agoston-Coldea L;Mocan L;Orasan R
纳米技术在广泛的医疗应用（诊断、治疗和预防各种疾病）方面有着巨大的前景。它们的优点是由于它们的尺寸，多功能性和多个同时应用的潜力。然而，由于有关纳米材料毒性的数据不足，科学界对此表示担忧。感兴趣的一个领域是由纳米颗粒和免疫系统的组成部分之间的相互作用表示。我们在此审查报告的数据超敏反应。研究了纳米颗粒在过敏原驱动机制中的免疫刺激和免疫抑制作用，以及全球研究的未来趋势。
Nanotechnology holds a great promise for a wide range of medical-intent applications (diagnostic, treatment and prophylaxis of various diseases). Their advantages are due to their size, versatility and potential for multiple simultaneous applications. However, concerns have been formulated by scientific world due to insufficient data on toxicity of nanomaterials. One area of interest is represented by the interactions between nanoparticles and the components of the immune system. We review herein reported data on hypersensitivity reactions. The role exerted by nanoparticles in both immunostimulation and immunosuppression in allergen-driven mechanisms was studied, as well as future trends in worldwide research.