Preparation, Isolation and Characterization of all of the Regioisomeric 61,6n‐Bis‐O‐(monomethoxytrityl) and ‐(dimethoxytrityl) Derivatives of Cyclomaltooligosaccharides.
Preparation, Isolation and Characterization of all of the Regioisomeric 61,6n‐Bis‐O‐(monomethoxytrityl) and ‐(dimethoxytrityl) Derivatives of Cyclomaltooligosaccharides.
复制标题
环麦芽寡糖所有区域异构体 61,6n-双-O-（单甲氧基三苯甲基）和 61,6n-双-O-（二甲氧基三苯甲基）衍生物的制备、分离和表征。
DOI：
10.1002/chin.199817224
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
K. Koizumi
中科院分区：
文献类型：
--
作者：
T. Tanimoto;A. Ikuta;K. Koizumi
通过环麦芽六糖（1、cG6、αCD）反应制备区域异构体 61, 6n-双-O-（单甲氧基三苯甲基）或 61, 6n-双-O-（二甲氧基三苯甲基）环麦芽六糖、-环麦芽七糖 (n = 2-4) 和 -环麦芽八糖衍生物 (n = 2-5)，环麦芽七糖（11，cG7，βCD）或环麦芽八糖（21，cG8，γCD）和4-单甲氧基三苯甲基氯或4,4'-二甲氧基三苯甲基氯的吡啶溶液。通过HPLC分离产物。这些位置异构体的区域化学测定是通过将这些化合物转化为各自的 61, 6n-双-O-(叔丁基二甲基甲硅烷基)衍生物1来完成的，其结构已经确定。
Regioisomeric 61, 6n-bis-O-(monomethoxytrityl) or 61, 6n-bis-O-(dimethoxytrityl) cyclomaltohexaose, -cyclomaltoheptaose (n = 2-4), and -cyclomaltooctaose derivatives (n = 2-5) were prepared by the reaction of cyclomaltohexaose (1, cG6, αCD), cyclomaltoheptaose (11, cG7, βCD) or cyclomaltooctaose (21, cG8, γCD) and 4-monomethoxytrityl chloride or 4,4′-dimethoxytrityl chloride in pyridine. Products were isolated by HPLC. The regiochemical determination of these positional isomers was done by converting these compounds to the respective 61, 6n-bis-O-(tert-butyldimethylsilyl) derivatives1whose structures have been already established.