Peripheral Choroidal Response to Localized Defocus Blur: Influence of Native Peripheral Aberrations.
Peripheral Choroidal Response to Localized Defocus Blur: Influence of Native Peripheral Aberrations.
复制标题
周边脉络膜对局部散焦模糊的反应：原生周边像差的影响。
DOI：
10.1167/iovs.65.4.14
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发表时间：
2024
影响因子：
4.4
通讯作者：
Yoon,Geunyoung
中科院分区：
文献类型：
--
作者：
Pusti,Dibyendu;Patel,NimeshB;Ostrin,LisaA;Nti,AugustineN;Das,Siddarth;Yoon,Geunyoung
目的：本研究的目的是检查短期周边脉络膜厚度（PChT）的反应，签署散焦模糊，无论有和没有自然周边像差。这项检查将提供洞察周边像差在检测信号的散焦。方法：周边视网膜（颞15）的右眼暴露于本地化的视频刺激在11个年轻的成年人的作用。自适应光学系统将2D近视或远视散焦诱导到刺激物上，具有或不具有校正原生周边眼像差（自适应光学[AO]或NoAO散焦条件）。使用Heidelberg Spectralis OCT在基线、暴露（10、20和30分钟）和恢复期（4、8和15分钟）捕获脉络膜扫描。基于神经网络的自动MATLAB分割程序测量了OCT扫描的PChT变化，统计分析评估了不同光学条件随时间的影响。结果：在曝光阶段，NoAO近视和远视散焦条件表现出明显的双向PChT变化，分别显示平均增厚（10.0±5.3 µm）和变薄（− 9.1±5.5 µm）。相比之下，诱导AO散焦条件未显示出较基线的显著变化。所有条件下PChT均恢复至基线。未曝光的中央凹没有表现出任何显着的ChT的变化，表明本地化的ChT响应retinal blurge.Conclusions：我们发现，PChT响应作为检测周边视网膜近视和远视散焦模糊的标记，特别是在周边像差的存在下。这些发现突出了周边定向模糊提示周边散焦标志检测的重要作用。
Purpose: This study aims to examine the short-term peripheral choroidal thickness (PChT) response to signed defocus blur, both with and without native peripheral aberrations. This examination will provide insights into the role of peripheral aberration in detecting signs of defocus.Methods: The peripheral retina (temporal 15) of the right eye was exposed to a localized video stimulus in 11 young adults. An adaptive optics system induced 2D myopic or hyperopic defocus onto the stimulus, with or without correcting native peripheral ocular aberrations (adaptive optics [AO] or NoAO defocus conditions). Choroidal scans were captured using Heidelberg Spectralis OCT at baseline, exposure (10, 20, and 30 minutes), and recovery phases (4, 8, and 15 minutes). Neural network-based automated MATLAB segmentation program measured PChT changes from OCT scans, and statistical analysis evaluated the effects of different optical conditions over time.Results: During the exposure phase, NoAO myopic and hyperopic defocus conditions exhibited distinct bidirectional PChT alterations, showing average thickening (10.0±5.3 µm) and thinning (− 9.1±5.5 µm), respectively. In contrast, induced AO defocus conditions did not demonstrate a significant change from baseline. PChT recovery to baseline occurred for all conditions. The unexposed fovea did not show any significant ChT change, indicating a localized ChT response to retinal blur.Conclusions: We discovered that the PChT response serves as a marker for detecting peripheral retinal myopic and hyperopic defocus blur, especially in the presence of peripheral aberrations. These findings highlight the significant role of peripheral oriented blur in cueing peripheral defocus sign detection.