RAPID EVOLUTION OF RNA GENOMES
RAPID EVOLUTION OF RNA GENOMES
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DOI：
10.1126/science.7041255
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
VANDEPOL, S
中科院分区：
文献类型：
--
作者：
HOLLAND, J;SPINDLER, K;VANDEPOL, S
RNA病毒显示出高突变频率，部分原因是缺乏确保DNA复制保真度的校对酶。这种高突变频率与高复制率相结合，反映在RNA基因组进化速度上，其速度可能比宿主DNA染色体进化速度高出100多万倍。在这个快速进化的RNA生物圈中，以dna为基础的生物圈有一些疾病的含义。
RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication. This high mutation frequency is coupled with high rates of replication reflected in rates of RNA genome evolution which can be more than a million-fold greater than the rates of the DNA chromosome evolution of their hosts. There are some disease implications for the DNA-based biosphere of this rapidly evolving RNA biosphere.