Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
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DOI：
10.1079/bjn20051462
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发表时间：
2005-07-01
影响因子：
3.6
通讯作者：
Hercberg, S
中科院分区：
文献类型：
--
作者：
Galan, P;Briancon, S;Hercberg, S
SUpplementation en Vitamines et Mineraux AntioXydants（SU.VI.MAX）研究是一项随机、双盲、一级预防试验，结果显示，在7个中心点5年后，低剂量的抗氧化剂补充剂降低了男性的总癌症发病率，但对女性没有影响。为了解释抗氧化剂补充剂对男性和女性影响的差异，我们假设补充剂的效果取决于初始抗氧化剂状态; 12741名法国成年人（35-60岁女性7 713人; 5028名45-60岁的男性）接受每日抗氧化剂补充（每天120毫克维生素C、30毫克维生素E、6毫克β-胡萝卜素、100微克硒、20毫克锌）或匹配的安慰剂。对于男性和女性，不同抗氧化维生素和矿物质的基线血清浓度的截止限定义如下：β-胡萝卜素为0中心点3 μ mol/l，维生素C为11中心点4 μ mol/l，维生素E为15 μ mol/l，硒为0中心点75 μ mol/l，锌为10中心点7 μ mol/l。患有癌症的男性血清中维生素C、E和β-胡萝卜素浓度低于临界值的比例高于未患癌症的男性。血清维生素C或维生素E基线浓度低于临界值的男性患癌症的风险更高，但女性则不然。维生素C、维生素E和β-胡萝卜素的基线血清浓度低于临界值的男性，补充维生素C、维生素E和β-胡萝卜素的效果比高于临界值的男性更好。在调整年龄、吸烟、饮酒和体重指数后，只有维生素E的效果保持不变。在女性中看不到补充剂的效果。基线抗氧化剂状态与男性癌症风险相关，但与女性无关，因此不能完全解释SU.VI.MAX研究中观察到的抗氧化剂补充剂对性别之间癌症风险影响的差异。
The SUpplementation en VItamines et Mineraux AntioXydants (SU.VI.MAX) study, a randomised double-blind, primary-prevention trial showed that after 7 center dot 5 years, low-dose antioxidant supplementation lowered the total cancer incidence in men, but not in women. To explain this difference in the impact of antioxidant supplementation in men and women, we hypothesised that the effect of supplementation is dependent on initial antioxidant status; 12 741 French adults (7713 females aged 35-60 years; 5028 males aged 45-60 years) received daily antioxidant supplementation (120 mg vitamin C, 30 mg vitamin E, 6 mg beta-carotene, 100 mu g Se, 20 mg Zn daily) or a matching placebo. Cut-off limits for baseline serum concentrations of the different antioxidant vitamins and minerals were defined as follows for both men and women: 0 center dot 3 mu mol/l for beta-carotene, 11 center dot 4 mu mol/l for vitamin C, 15 mu mol/l for vitamin E, 0 center dot 75 mu mol/l for Se and 10 center dot 7 mu mol/l for Zn. The percentage of men with serum concentrations under cut-off limits was higher for vitamins C and E and beta-carotene in those who developed a cancer than in those who did not. The risk of cancer was higher in men with baseline concentrations of serum vitamin C or vitamin E under cut-off limits, but not in women. The effect of supplementation was greater in men with baseline serum concentrations of vitamin C, vitamin E and beta-carotene below the cut-off limits compared with those above it. This effect was maintained only for vitamin E after adjustment for age, tobacco, and alcohol consumption and BMI. No effect of supplementation could be seen in women. Baseline antioxidant status is related to the risk of cancer in men but not in women and therefore does not entirely explain the differences observed in the effect of antioxidant supplementation on cancer risk between sexes in the SU.VI.MAX study.