A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis
A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis
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DOI：
10.1016/j.ntt.2003.07.018
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发表时间：
2003-11-01
影响因子：
2.9
通讯作者：
Martsolf, JT
中科院分区：
文献类型：
--
作者：
Klug, MG;Burd, L;Martsolf, JT
特定发育障碍的个体风险标记的流行率和影响程度在不同诊断类别中差异很大。该项目的四个研究队列是来自北达科他州四个胎儿酒精综合症（FAS）、自闭症、婴儿猝死综合症（SIDS）和图雷特综合症诊断登记处的患者。这四个队列用于估计发育障碍患者中父母风险标记的患病率和影响程度。具有北达科他州出生证明的病例与对照进行匹配。然后，我们使用出生证明数据检查了每个队列的五个父母风险标记，并按队列估计了每个风险标记的直接和间接影响。作者发现了两个重要的父亲风险标记（SIDS 中的年龄和 FAS 中的教育程度）。重要的母亲标志是 SIDS 的年龄、FAS 的教育程度、自闭症和 SIDS。婚姻状况是 FAS 的一个重要风险标志。使用配对 t 检验、比值比和群体归因风险 (PAR) 来估计每个标记的直接和间接效应的效应大小。我们估计了直接和间接影响，以便直接比较每个标记的差异效应估计。父母标记物的直接影响在不同的患者诊断队列中是不同的。使用从流行率研究中获得的相似分母人群的队列是估计风险标记的流行率和影响程度的有用方法工具。 (C) 2003 Elsevier Inc. 保留所有权利。
The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SIDS), and Tourette syndrome. These four cohorts were used to estimate prevalence and magnitude of effect of parental risk markers in patients with developmental disabilities. Cases with North Dakota birth certificates were matched with controls. Using birth certificate data, we then examined five parental risk markers for each cohort and estimated direct and indirect effects for each risk marker by cohort. The authors found two significant paternal risk markers (age in SIDS and education in FAS). Significant maternal markers were age in SIDS, education in FAS, autism, and SIDS. Marital status was a significant risk marker in FAS. Effect sizes were estimated using paired t tests, odds ratios, and population attributable risk (PAR) for both direct and indirect effects for each marker. We estimated both direct and indirect effects to allow for direct comparisons of the differential effect estimates of each of these markers. The direct effect of parental markers differs across diagnostic cohorts of patients. Use of cohorts from similar denominator populations obtained from prevalence studies is a useful methodological tool for estimating the prevalence and magnitude of effect of risk markers. (C) 2003 Elsevier Inc. All rights reserved.