Respiratory syncytial virus-specific cell-mediated immune responses after vaccination with a purified fusion protein subunit vaccine.
Respiratory syncytial virus-specific cell-mediated immune responses after vaccination with a purified fusion protein subunit vaccine.
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DOI：
10.1093/infdis/170.2.425
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发表时间：
1994-08
期刊：
影响因子：
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通讯作者：
R. Welliver;Debra A. Tristram;Kathleen Batt;Martha Sun;A. HogermanDeborah;Steven Hildreth
中科院分区：
文献类型：
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作者：
R. Welliver;Debra A. Tristram;Kathleen Batt;Martha Sun;A. HogermanDeborah;Steven Hildreth
用呼吸道合胞病毒（RSV）融合蛋白亚单位疫苗（PFP-2）接种，以确定该疫苗是否诱导细胞介导的RSV免疫证据，以及细胞介导的免疫是否阻止RSV再感染。12-18个月大的健康儿童接受50微克PFP-2或生理盐水对照。接种前、接种后1个月和6个月测定淋巴细胞转化（LTF）反应。PFP-2诱导6名缺乏细胞介导免疫证据的受试者中有5名（83%）出现LTF阳性反应。接种疫苗样本的LTF阳性反应没有增强，但接种疫苗的人比对照组更持久。LTF阳性反应与对后续感染的保护无关。PFP-2免疫诱导细胞介导免疫的相关因子，但这种免疫似乎不是保护的关键组成部分。
Vaccination with a respiratory syncytial virus (RSV) fusion protein subunit vaccine (PFP-2) was done to determine if this vaccine induced evidence of cell-mediated immunity to RSV and if cell-mediated immunity prevented RSV reinfection. Healthy children 12-18 months old received 50 micrograms of PFP-2 or a saline control. Lymphocyte transformation (LTF) responses were determined before and 1 and 6 months after vaccination. PFP-2 induced positive LTF responses in 5 (83%) of 6 subjects whose prevaccination samples lacked evidence of cell-mediated immunity. Positive LTF responses in prevaccination samples were not boosted but were more persistent in vaccinees than in controls. Positive LTF responses were not associated with protection against subsequent infection. Immunization with PFP-2 induces correlates of cell-mediated immunity, but this immunity does not appear to be a critical component of protection.