The role of microRNAs in bone remodeling.
The role of microRNAs in bone remodeling.
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微小核糖核酸（miRNA）在骨重塑中的作用。
DOI：
10.1038/ijos.2015.22
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发表时间：
2015-09-14
影响因子：
14.9
通讯作者：
Zhao ZH
中科院分区：
文献类型：
--
作者：
Jing D;Hao J;Shen Y;Tang G;Li ML;Huang SH;Zhao ZH
骨重建通过骨形成和骨吸收以及种子细胞数量和功能的改变来平衡，导致骨状态的维持或恶化。已有证据表明，microRNAs（miRNAs）是一类短的非编码RNA家族，是基因表达的关键转录后抑制因子，越来越多的新型miRNAs被证实在骨形成、破骨细胞形成和脂肪形成的调控中发挥重要作用，揭示了它们如何与信号分子相互作用来控制这些过程。本文综述了目前有关miRNA在调节骨重建中的作用的知识，以及miRNA在生物材料中用于治疗目的的新应用。
Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.