A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations
A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations
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DOI：
10.1088/1478-3967/2/1/002
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发表时间：
2005-03-01
期刊：
影响因子：
2
通讯作者：
Milotti, E
中科院分区：
文献类型：
--
作者：
Chignola, R;Milotti, E
现代计算生物学的一个主要目标是从微观水平上发生的分子相互作用的复杂网络开始模拟大细胞群体的集体行为。在本文中，我们描述了一个简化的模型，细胞代谢，生长和增殖，适合于包含在一个多细胞模拟器，现在正在开发中（Chignola R和Milotti E 2004年物理A 338 261 - 6）。营养素调节肿瘤细胞的增殖动力学，使其行为适应环境生化组成的变化。这种营养代谢和细胞周期在介观尺度水平的建模导致两个不同的时空尺度的分子和细胞动力学之间的信息的连续流动，可以用现代计算机模拟和实验测试。
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a simplified model of cell metabolism, growth and proliferation, suitable for inclusion in a multicell simulator, now under development (Chignola R and Milotti E 2004 Physica A 338 261 - 6). Nutrients regulate the proliferation dynamics of tumour cells which adapt their behaviour to respond to changes in the biochemical composition of the environment. This modelling of nutrient metabolism and cell cycle at a mesoscopic scale level leads to a continuous flow of information between the two disparate spatiotemporal scales of molecular and cellular dynamics that can be simulated with modern computers and tested experimentally.