Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.
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DOI：
10.1016/j.cmet.2014.11.001
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发表时间：
2014-12-02
期刊：
影响因子：
29
通讯作者：
Panda S
中科院分区：
文献类型：
--
作者：
Chaix A;Zarrinpar A;Miu P;Panda S
由于目前治疗肥胖症的方法有限，而且只能提供适度的改善，因此需要新的干预措施。通过限时喂食(TRF；活动期8-9小时进食)预防肥胖是有希望的，但它对先前存在的肥胖症、多样化的营养挑战和不那么严格的饮食模式的治疗适用性尚不清楚。在这里，我们在不同营养挑战下的小鼠身上测试了TRF。我们发现，TRF可减轻由各种肥胖饮食引起的代谢性疾病，其益处与禁食时间成正比。此外，即使在TRF因周末随意获取食物而暂时中断的情况下，保护效果仍保持不变，这是一种与人类生活方式特别相关的养生方式。最后，TRF稳定并逆转了既往肥胖和II型糖尿病小鼠代谢性疾病的进展。我们建立了TRF的临床相关参数，用于预防和治疗肥胖和代谢紊乱，包括II型糖尿病、肝脏脂肪变性和高胆固醇血症。
Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9h food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse nutritional challenges, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with pre-existing obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
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影响因子：
5.2
作者：
McArdle MA;Finucane OM;Connaughton RM;McMorrow AM;Roche HM
通讯作者：
Roche HM
影响因子：
64.5
作者：
Narkar VA;Downes M;Yu RT;Embler E;Wang YX;Banayo E;Mihaylova MM;Nelson MC;Zou Y;Juguilon H;Kang H;Shaw RJ;Evans RM
通讯作者：
Evans RM
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
DOI：
10.1073/pnas.1118726109
发表时间：
2012-04-03
影响因子：
11.1
作者：
Eckel-Mahan, Kristin L.;Patel, Vishal R.;Sassone-Corsi, Paolo
通讯作者：
Sassone-Corsi, Paolo
影响因子：
15.9
作者：
Matsusue, K;Haluzik, M;Gonzalez, FJ
通讯作者：
Gonzalez, FJ