Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine
Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine
复制标题
DOI：
10.1016/j.biopsycho.2004.11.008
复制
发表时间：
2005-04-01
影响因子：
2.6
通讯作者：
Staud, R
中科院分区：
文献类型：
--
作者：
Fillingim, RB;Hastie, BA;Staud, R
近年来，疼痛感知和镇痛反应的性别差异越来越受到关注。我们在49名健康女性和39名男性中研究了心理因素与基线疼痛感知和喷他佐辛镇痛的相关性。受试者完成心理问卷测量积极和消极的影响，以及灾难化。随后，在双盲静脉注射喷他佐辛（0.5 mg/kg）之前和之后评估对实验性疼痛的反应。在相关性分析中，积极的情感预测男性而不是女性的疼痛敏感性较低。负性情绪预测了较低的基线疼痛耐受性在两种性别，但预测较差的镇痛只有男性。灾难化与更大的疼痛敏感性和更少的镇痛更一致的男性比女性。回归模型显示，积极的影响预测整体疼痛敏感性较低，灾难化预测整体镇痛反应较差的男性，而没有显着的预测整体疼痛或镇痛出现的女性。此外，积极情绪和灾难化分别与药物的副作用呈负相关和正相关，但仅限于男性。这些研究结果表明，性别依赖性协会的心理因素与基线疼痛感知，镇痛反应，药物副作用。(c)2004 Elsevier B. V.保留所有权利。
Sex differences in pain perception and analgesic responses have garnered increasing attention in recent years. We examined the association of psychological factors to baseline pain perception and pentazocine analgesia among 49 healthy women and 39 men. Subjects completed psychological questionnaires measuring positive and negative affect as well as catastrophizing. Subsequently, responses to experimental pain were assessed before and after double-blind administration of intravenous pentazocine (0.5 mg/kg). In correlational analyses, positive affect predicted lower pain sensitivity among men but not women. Negative affect predicted lower baseline pain tolerances among both sexes but predicted poorer analgesia only among men. Catastrophizing was associated with greater pain sensitivity and less analgesia more consistently in men than women. Regression models revealed that positive affect predicted lower overall pain sensitivity and catastrophizing predicted poorer overall analgesic responses among men, while no significant predictors of overall pain or analgesia emerged for women. Moreover, positive affect and catastrophizing were negatively and positively correlated, respectively, with side effects from the medication, but only among men. These findings indicate sex-dependent associations of psychological factors with baseline pain perception, analgesic responses, and medication side effects. (c) 2004 Elsevier B.V. All rights reserved.