Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.
Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.
复制标题
二氟甲基鸟氨酸增强前列腺对腐胺的摄取：简洁的沟通。
作者：
D. Kadmon;W. Heston;D. W. Lazan;W. Fair
我们研究了α-二氟甲基鸟氨酸（DFMO），一种不可逆的鸟氨酸脱羧酶抑制剂，对腐胺摄取的大鼠前列腺的影响。使用C-14腐胺，我们发现，与未处理的对照组相比，DFMO预处理的完整动物的背侧和腹侧前列腺的摄取增加了几倍。当先前阉割的动物用睾酮和DFMO的组合治疗时，前列腺对外源性施用的C-14腐胺的摄取增加了十倍以上。在这些条件下，DFMO增强前列腺的吸收，在更大程度上比任何其他组织的研究。
We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine increased more than tenfold. Under these conditions, DFMO enhanced the uptake by the prostate to a greater extent than by any other tissue studies.