Augmentation and impulsive behaviors in restless legs syndrome: Coexistence or association?
Augmentation and impulsive behaviors in restless legs syndrome: Coexistence or association?
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DOI：
10.1212/wnl.0000000000002803
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发表时间：
2016-07-05
期刊：
影响因子：
9.9
通讯作者：
Hoegl, Birgit
中科院分区：
文献类型：
--
作者：
Heim, Beatrice;Djamshidian, Atbin;Hoegl, Birgit
目的：通过一项病例对照研究，评估多巴胺能治疗下不宁腿综合征（RLS）患者（有或无增强）冲动控制障碍（ICD）的发生率。增强和ICD都是严重的并发症，多巴胺能治疗的RLS，但鲜为人知的是，这些药物诱导的disorders.Methods之间可能存在的关联：共招募了58例特发性RLS诊断根据国际不宁腿综合征研究组的标准。其中，35名患者接受了隆乳。ICD症状的频率进行了评估，使用半结构interviews.Results：人口统计学变量没有显着差异与RLS与增强和不增强，但那些增强了多巴胺能药物比患者没有增强。23例RLS患者（39.7%）有ICD症状，12例患者（20.7%）有明确的ICD。增强患者有增加的风险表达ICD症状（p = 0.007，比值比5.64，95%置信区间1.59-20.02）。结论：RLS增强患者有近6倍的风险增加表现出ICD症状。这意味着增强和ICD是相关的，并且可能具有共同的病理生理学。此外，我们的研究结果具有临床意义，表明RLS增强患者应筛查ICD症状。
Objectives:To assess the frequency of impulse control disorders (ICDs) in patients with restless legs syndrome (RLS) with and without augmentation under dopaminergic therapy in a case-control study. Augmentation and ICDs are both serious complications of dopaminergic treatment of RLS but little is known about possible associations between these drug-induced disorders.Methods:In total, 58 patients with idiopathic RLS diagnosed according to the International Restless Legs Syndrome Study Group criteria were recruited. Of these, 35 patients had augmentation. The frequency of ICD symptoms was assessed using semi-structural interviews.Results:Demographic variables did not differ between patients with RLS with and without augmentation but those with augmentation took higher dopaminergic medication than patients without augmentation. Twenty-three patients with RLS (39.7%) had ICD symptoms, with 12 patients (20.7%) having definitive ICDs. Patients with augmentation had an increased risk of expressing ICD symptoms (p = 0.007, odds ratio 5.64, 95% confidence interval 1.59-20.02).Conclusions:Patients with RLS with augmentation have an almost 6-fold increased risk of exhibiting ICD symptoms. This implies that augmentation and ICDs are related and may share a common pathophysiology. Moreover, our results have clinical implications, suggesting that patients with RLS with augmentation should be screened for ICD symptoms.