TREATMENT OF RABBIT LIVER CANCER IN VIVO USING MINIATURIZED IMAGE-ABLATE ULTRASOUND ARRAYS
TREATMENT OF RABBIT LIVER CANCER IN VIVO USING MINIATURIZED IMAGE-ABLATE ULTRASOUND ARRAYS
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DOI：
10.1016/j.ultrasmedbio.2011.05.850
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发表时间：
2011-10-01
影响因子：
2.9
通讯作者：
Rudich, Steven M.
中科院分区：
文献类型：
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作者：
Mast, T. Douglas;Barthe, Peter G.;Rudich, Steven M.
在这里报道的临床前研究中，兔肝VX2癌已通过采用小型化图像消融阵列的体超声消融治疗。阵列探针由32个元件组成，孔径为2.3 x 20 mm(2)，封装在3.1 mm的不锈钢管中，带有冷却和耦合气囊，用于体内使用。测量结果表明，该探针具有50%的脉冲回波成像分数带宽（中心频率4.4 MHz），在3.5和4.8 MHz的超声频率下可获得>110 W/cm(2)的表面强度。该阵列的b扫描成像性能可与较大的诊断线性阵列相媲美，尽管近场图像质量因环形伪影而降低。采用无聚焦32元孔径4.8 MHz发射，曝光持续时间20-70.5 s，原位空间平均和时间平均强度22.4-38.5 W/cm(2)，进行了一系列体内消融过程。12次暴露中有7次通过活体染色证实了完整的肿瘤横切面消融，其中4次暴露在肿瘤以外的所有方向上消融了额外的边缘bbb10 - 1mm。分析表明，阈值消融效应，在释放bbbb838j声能的情况下，完全消融肿瘤横切面。结果表明，采用适合于间隙部署的小型化图像消融阵列在体内进行肝癌消融是可行的。（E-mail: doug.mast@uc.edu） (C) 2011年世界超声医学与生物学联合会。
In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3 x 20 mm(2) aperture, packaged within a 3.1 mm stainless steel tube with a cooling and coupling balloon for in vivo use. The probes were measured capable of 50% fractional bandwidth for pulse-echo imaging (center frequency 4.4 MHz) with >110 W/cm(2) surface intensity available at sonication frequencies 3.5 and 4.8 MHz. B-scan imaging performance of the arrays was measured to be comparable to larger diagnostic linear arrays, although nearfield image quality was reduced by ringdown artifacts. A series of in vivo ablation procedures was performed using an unfocused 32-element aperture firing at 4.8 MHz with exposure durations 20-70.5 s and in situ spatial average, temporal average intensities 22.4-38.5 W/cm(2). Ablation of a complete tumor cross-section was confirmed by vital staining in seven of 12 exposures, with four exposures ablating an additional margin >1 mm beyond the tumor in all directions. Analysis suggests a threshold ablation effect, with complete ablation of tumor cross-sections for exposures with delivery of >838 J acoustic energy. The results show feasibility for in vivo liver cancer ablation using miniaturized image-ablate arrays suitable for interstitial deployment. (E-mail: doug.mast@uc.edu) (C) 2011 World Federation for Ultrasound in Medicine & Biology.