Design of Multiresponsive Hydrogel Particles and Assemblies
Design of Multiresponsive Hydrogel Particles and Assemblies
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DOI：
10.1002/adfm.200902429
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发表时间：
2010-06-09
影响因子：
19
通讯作者：
Lyon, L. Andrew
中科院分区：
文献类型：
--
作者：
Hendrickson, Grant R.;Smith, Michael H.;Lyon, L. Andrew
在软纳米技术领域，水凝胶微米和纳米颗粒代表了一类通用的响应材料。在过去的十年中，我们的团队研究了各种合成水凝胶颗粒的合成和物理化学性质。通过这些努力，已经出现了几种具有潜在生物应用功能的颗粒类型，包括用于靶向药物递送的纳米凝胶，用于生物传感的微透镜和用于生物医学设备的涂层。例如，核/壳纳米凝胶已被用于封装和递送小干扰RNA到卵巢癌细胞;以这种方式使用的纳米凝胶可以改善各种大分子疗法的治疗效果。在可植入生物材料上排列成多层的微凝胶极大地减少了宿主对材料的炎症反应。此外，药物的触发释放（即，胰岛素）已经从类似的组件中得到证实。这篇专题文章的目的是强调在我们最近的努力背景下，以及与围绕这类迷人材料成长起来的社区相关的响应性微凝胶和纳米凝胶设计的发展。
In the realm of soft nanotechnology, hydrogel micro- and nanoparticles represent a versatile class of responsive materials. Over the last decade, our group has investigated the synthesis and physicochemical properties of a variety of synthetic hydrogel particles. From these efforts, several particle types have emerged with potentially enabling features for biological applications, including nanogels for targeted drug delivery, microlenses for biosensing, and coatings for biomedical devices. For example, core/shell nanogels have been used to encapsulate and deliver small interfering RNA to ovarian cancer cells; nanogels used in this fashion may improve therapeutic outcomes for a variety of macromolecular therapeutics. Microgels arranged as multilayers on implantable biomaterials greatly minimize the host inflammatory response to the material. Furthermore, the triggered release of drugs (i.e., insulin) has been demonstrated from similar assemblies. The goal of this feature article is to highlight developments in the design of responsive microgels and nanogels in the context of our recent efforts and in relation to the community that has grown up around this fascinating class of materials.