Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges.
Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges.
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DOI：
10.3390/ijms232112956
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发表时间：
2022-10-26
影响因子：
5.6
通讯作者：
Mohapatra, Subhra
中科院分区：
文献类型：
--
作者：
Green, Ryan;Khalil, Roukiah;Mohapatra, Shyam S.;Mohapatra, Subhra
目前，人们对使用大麻二酚（CBD）来缓解癌症引起的症状越来越感兴趣，包括疼痛、睡眠中断和焦虑。CBD通常作为一种非处方补充剂自行服用，患者也报告了其使用的益处。然而，尽管取得了进展，CBD抗癌活性的机制仍然存在分歧和不清楚。在此，我们从临床前和临床研究中全面综述了确定CBD趋同抗癌作用的分子机制。体外研究已经开始阐明CBD的分子靶点，并为CBD在肿瘤细胞和小鼠模型中的抗肿瘤特性提供证据。此外，已经完成了几项临床试验，测试CBD治疗癌症相关疼痛的疗效。然而，大多数人使用CBD和精神活性物质四氢大麻酚（THC）的混合物，和/或使用个体患者之间不一致的可变剂量。尽管存在这些限制，但据报道，在使用CBD或CBD+THC的癌症患者中，疼痛和阿片类药物的使用显著减少。此外，据报道，在生活质量测量和患者对治疗的总体满意度方面也有显著改善。因此，越来越多的证据表明，CBD可能有助于改善癌症患者的整体生活质量，既可以减轻癌症症状，又可以与癌症疗法协同提高疗效。然而，关于在癌症治疗中使用CBD的许多问题仍未得到解答，包括最佳剂量，与其他药物的有效组合，以及哪些生物标志物/临床症状可能指导其使用。
There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self-administered as an over-the-counter supplement, and patients have reported benefits from its use. However, despite the progress made, the mechanisms underlying CBD’s anti-cancer activity remain divergent and unclear. Herein, we provide a comprehensive review of molecular mechanisms to determine convergent anti-cancer actions of CBD from pre-clinical and clinical studies. In vitro studies have begun to elucidate the molecular targets of CBD and provide evidence of CBD’s anti-tumor properties in cell and mouse models of cancer. Furthermore, several clinical trials have been completed testing CBD’s efficacy in treating cancer-related pain. However, most use a mixture of CBD and the psychoactive, tetrahydrocannabinol (THC), and/or use variable dosing that is not consistent between individual patients. Despite these limitations, significant reductions in pain and opioid use have been reported in cancer patients using CBD or CBD+THC. Additionally, significant improvements in quality-of-life measures and patients’ overall satisfaction with their treatment have been reported. Thus, there is growing evidence suggesting that CBD might be useful to improve the overall quality of life of cancer patients by both alleviating cancer symptoms and by synergizing with cancer therapies to improve their efficacy. However, many questions remain unanswered regarding the use of CBD in cancer treatment, including the optimal dose, effective combinations with other drugs, and which biomarkers/clinical presentation of symptoms may guide its use.
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影响因子：
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