Exploring the genetics of longevity in the Old Order Amish
Exploring the genetics of longevity in the Old Order Amish
复制标题
DOI：
10.1016/j.mad.2004.08.027
复制
发表时间：
2005-02-01
影响因子：
5.3
通讯作者：
Shuldiner, AR
中科院分区：
文献类型：
--
作者：
Sorkin, J;Post, W;Shuldiner, AR
寿命是由遗传和环境因素相互作用决定的复杂表型。这使得识别影响寿命的基因变异变得具有挑战性。我们相信宾夕法尼亚州兰开斯特的旧秩序阿米什人 (OOA) 是研究长寿遗传学的优秀人群。他们是由有限数量的创始人衍生出来的封闭群体。他们拥有大家庭，并保存着可追溯到 1700 年代的大量家谱记录。他们避开现代技术；他们的生活方式在过去 250 年里几乎没有改变。不同时间和不同 OOA 人群的环境和生活方式因素的同质性最大限度地减少了环境因素对个体寿命差异的影响。我们假设环境变异性的减少将使人们更容易识别影响寿命的遗传因素。在本文中，我们描述了识别影响阿米什人寿命的基因变异的策略，并介绍了我们迄今为止的研究结果。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Lifespan is a complex phenotype determined by the interaction of genetic and environmental factors. This makes the identification of variants in genes that influence longevity challenging. We believe that the Old Order Amish (OOA) of Lancaster, Pennsylvania is an excellent population for studying the genetics of longevity. They are a closed population derived from a limited number of founders. They have large families and maintain extensive genealogic records dating to the 1700 s. They eschew modem technology; their lifestyle is little changed over the last 250 years. Homogeneity of environment and lifestyle factors across time and across the OOA population minimizes the influence that environmental factors have in determining the differences in lifespan between individuals. We hypothesize that this reduction in environmental variability will make it easier to identify the genetic factors that influence lifespan. In this article, we describe our strategy for identifying variants in genes that influence longevity in the Amish and present the results of our studies to date. (C) 2004 Elsevier Ireland Ltd. All rights reserved.