A UNITARY ANALYSIS OF PULMONARY VOLUME RECEPTORS
A UNITARY ANALYSIS OF PULMONARY VOLUME RECEPTORS
复制标题
DOI：
10.1152/ajplegacy.1946.147.1.100
复制
发表时间：
1946-01-01
影响因子：
--
通讯作者：
LARRABEE, MG
中科院分区：
文献类型：
--
作者：
KNOWLTON, GC;LARRABEE, MG
在Dial麻醉下记录猫迷走神经单支传入纤维对肺容积变化的反应。根据终末器官适应肺充气的速率，可将纤维分为两组。慢适应受体在平均动脉压上的分布。比快速适应的受体更低的膨胀阈值。这两种受体中的一些对肺的强制放气有反应，但没有发现只对放气有反应的受体。在20根纤维中测量并根据体温校正的传导速度，在8到44米/秒之间。与肺膨胀引起的2种反射相比，2种传入纤维组的适应性和阈值的差异表明，来自慢适应末梢的冲动抑制吸气，而来自快适应末梢的冲动激发吸气。这种功能评价充分说明了对肺充气和放气的呼吸反应。正常呼吸中只有缓慢适应的纤维在起作用。它们的阈值的变化有助于呼吸过度时呼吸速率的增加。快速适应纤维的主要功能似乎是加强某些深层灵感的深度，这些灵感是通过其他机制启动的。
The responses of single afferent fibers of the vagus nerve to changes in lung vol. were recorded in cats under Dial anesthesia. The fibers could be divided into 2 distinct groups according to the rate at which their end-organs adapted to lung inflation. The slowly adapting receptors had on the avg. a lower inflation threshold than the rapidly adapting receptors. Some of both these kinds responded to forced deflation of the lungs, but no receptors were found which responded only to deflation. The conduction velocity, measured in 20 fibers and corrected to body temp., was between 8 and 44 meters/sec. The differences in adaptation and threshold of the 2 afferent fiber groups, when compared with the 2 reflexes evoked by inflation of the lungs, suggest that impulses from slowly adapting endings inhibit inspiration, while those from the rapid adaptors excite inspiration. This evaluation of function adequately accounts for the respiratory responses to both inflation and deflation of the lungs. Only the slowly adapting fibers are in action in eupnea. A change in their threshold contributes to the increased rate of respiration in hyperpnea. The principle function of the rapidly adapting fibers appears to be a reinforcement of the depth of certain deep inspirations which have been initiated through other mechanisms.