An interferon-γ-related cytokine storm in SARS patients
An interferon-γ-related cytokine storm in SARS patients
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DOI：
10.1002/jmv.20255
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发表时间：
2005-02-01
影响因子：
12.7
通讯作者：
Lei, HY
中科院分区：
文献类型：
--
作者：
Huang, KJ;Su, IJ;Lei, HY
对88例经逆转录聚合酶链反应（RT - PCR）确诊的严重急性呼吸综合征（SARS）患者的14种细胞因子或趋化因子进行了分析。在中国台湾地区SARS患者的急性期血清中，干扰素 -γ、白细胞介素 - 18、转化生长因子 -β、白细胞介素 - 6、干扰素诱导蛋白10（IP - 10）、单核细胞趋化蛋白 - 1（MCP - 1）、干扰素诱导的单核因子（MIG）和白细胞介素 - 8显著升高，但肿瘤坏死因子 -α、白细胞介素 - 2、白细胞介素 - 4、白细胞介素 - 10、白细胞介素 - 13或肿瘤坏死因子受体I（TNFR I）没有升高。抗体阳性组的干扰素 -γ显著高于抗体阴性组。干扰素 -γ、白细胞介素 - 18、单核细胞趋化蛋白 - 1、干扰素诱导的单核因子和干扰素诱导蛋白10在发热后的早期就已经升高。此外，死亡组的白细胞介素 - 18、干扰素诱导蛋白10、干扰素诱导的单核因子和单核细胞趋化蛋白 - 1水平显著高于存活组。对于存活组，干扰素 -γ和单核细胞趋化蛋白 - 1与循环淋巴细胞计数和单核细胞计数呈负相关，但与循环中性粒细胞计数呈正相关。结论是，SARS冠状病毒感染后诱发了干扰素 -γ相关的细胞因子风暴，这种细胞因子风暴可能参与了SARS患者的免疫病理损伤。（C）2004威利 - 利斯公司
Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-gamma, IL-18, TGF-beta, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-alpha, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-gamma was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-gamma, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-gamma and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-gamma-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. (C) 2004 Wiley-Liss, Inc.