Editor's Choice - Fluid-Structure Interaction Simulations of Aortic Dissection with Bench Validation
Editor's Choice - Fluid-Structure Interaction Simulations of Aortic Dissection with Bench Validation
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DOI：
10.1016/j.ejvs.2016.07.006
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发表时间：
2016-11-01
影响因子：
5.7
通讯作者：
Kassab, G. S.
中科院分区：
文献类型：
--
作者：
Chen, H. Y.;Peelukhana, S. V.;Kassab, G. S.
引言：对主动脉夹层中瓣内的血流和应力还没有很好的了解。验证的流体结构相互作用（FSI）的血流和皮瓣之间的相互作用的模拟将提供洞察主动脉夹层的动力学，并可能导致新的therapeutic approaches.Methods的发展：一个耦合，双向血流和皮瓣壁计算模型的开发。使用任意拉格朗日-欧拉方法，该方法允许流体网格变形。结果：真腔（TL）和假腔（FL）的血流速度在实验室和模拟室之间无显著差异。实验室模拟和计算模拟之间循环期间TL %横截面积（CSA）的动态相似，TL %CSA在接近循环峰值收缩期时降低最多。实验远端测量值的流速明显较低，可能是由于远端的空间不均匀流动。验证了质量守恒和模拟的有效性。此外，在襟翼前缘、角部和整个血管壁上发现了应力集中区。FL上的压力梯度的结果在一个净力flape.Conclusion：FSI在TL和FL的流速，以及在心动周期的CSA的动力学进行了验证，通过台架实验。经验证的FSI模型可以提供对主动脉夹层的深入了解，包括夹层瓣上的应力和相关的流动干扰，这可能会被新的治疗方法所抑制。未来可以使用本研究中提供的经验证的计算平台开发更真实的人体主动脉夹层模拟和当前治疗方法（如覆膜支架）的效果。(C)2016年欧洲血管外科学会。由爱思唯尔有限公司出版。保留所有权利。
Introduction: The blood flow and stresses in the flap in aortic dissections are not well understood. Validated fluid structure interaction (FSI) simulations of the interactions between the blood flow and the flap will provide insight into the dynamics of aortic dissections and may lead to developments of novel therapeutic approaches.Methods: A coupled, two-way blood flow and flap wall computational model was developed. The Arbitrary Lagrange-Eulerian method was used, which allowed the fluid mesh to deform. Inflow velocity waveforms from a pulse duplicator system were used in the simulations.Results: The velocities for true lumen (TL) and false lumen (FL) were not significantly different between bench and simulation. The dynamics of the TL % cross-sectional area (CSA) during the cycle was similar between the bench and computational simulations, with the TL %CSA being most reduced near peak systole of the cycle. The experimental distal measurements had significantly lower velocities, likely due to the spatially heterogeneous flow distally. The conservation of mass and validity of simulations were confirmed. Additionally, regions of stress concentrations were found on the flap leading edge, towards the corners, and through the entire vessel wall. The pressure gradient across the FL results in a net force on the flap.Conclusion: The FSI flow velocities in the TL and the FL as well as the dynamics of the CSA during the cardiac cycle were validated by bench experiments. The validated FSI model may provide insights into aortic dissection including the stresses on the dissection flap and related flow disturbance, which may be subdued by novel therapeutic approaches. Simulations of more realistic human aortic dissections and the effects of current therapeutic approaches such as stent-graft can be developed in the future using the validated computational platform provided in the present study. (C) 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.