Radiological changes after medical treatment of vesical schistosomiasis.
Radiological changes after medical treatment of vesical schistosomiasis.
复制标题
膀胱血吸虫病药物治疗后的放射学变化。
DOI：
10.1016/s0140-6736(66)90826-9
复制
发表时间：
1966
期刊：
影响因子：
168.9
通讯作者：
H. Gilles
中科院分区：
文献类型：
--
作者：
A. Lucas;C. Adeniyi;W. Cockshott;H. Gilles
最近，几组工作人员显示了由血吸虫引起的地方性感染在非洲不同地区儿童尿路系统的严重变化频率[本公报，1962年，诉59,461；1964年，诉61,1221之二；1966，诉63,770]。如果不对受影响的儿童进行数年的观察，这些疾病的最终意义是无法确定的，尼日利亚伊巴丹正在为此进行的一项研究。本报告是关于最初在12名儿童中表现出的相当明显的泌尿系统异常的变化的报告，这些变化最初是在血吸虫感染的特定治疗(10名用Ambilhar治疗，2名用Lucanthone治疗)后的几周或几个月。3例结节状充盈缺损儿在治疗后25~60周复查膀胱造影正常，14周时发现类似的左输尿管扩张和肾积水消失。另2例有膀胱缺陷或双侧肾脏背压改变，但均伴有膀胱钙化的患儿，除钙化外的所有异常在27周和74周时均消失。2术后26周和28周复查时，有膀胱充盈缺陷和肾背压的患者也完全缓解。在12名儿童中，只有4名在特定治疗后14-26周重复静脉肾盂造影术时没有明显变化。一些优秀的放射照片说明了作者的发现。尽管数字很小，但这些结果是令人鼓舞的，因为它们表明血吸虫肉芽肿病变可以在没有显著残留损害的情况下消失。这对治疗政策的影响是显而易见的。
Recently, several groups of workers have shown the frequency of gross urological changes in children in various areas in Africa of endemicity of infections caused bySchistosoma haematobium[thisBulletin, 1962, v. 59, 461; 1964, v. 61, 1221bis; 1966, v. 63, 770]. The ultimate significance of these cannot be determined without observation of the affected children for some years, and a study to this end is in progress at Ibadan, Nigeria.The present is a report on the changes in the considerable urological abnormalities originally evident in 12 children, some weeks or months after specific treatment (10 treated with Ambilhar and 2 with lucanthone) for the schistosomal infections. The bladders of 3 children with nodular filling defects gave normal cystograms when re-examined at 25 to 60 weeks after treatment; a similar defect with dilatation of the left ureter and a hydronephrosis was found to have resolved at the fourteenth week. In 2 other children with bladder defects or back pressure changes in both kidneys, but both with bladder calcification, all abnormalities other than the calcification had vanished at 27 and 74 weeks. 2 further patients with bladder filling defects and renal back pressure were also entirely relieved of these defects when examined again after 26 and 28 weeks. In only 4 of the 12 children was there no significant change in the intravenous pyelograms when repeated 14 to 26 weeks after specific treatment. Some excellent radiographs illustrate the authors' findings.Though the figures are small these results are encouraging, as they suggest that schistosomal granulomatous lesions may resolve without significant residual damage. The implications in respect of treatment policy are obvious.A. R. D. Adams.