Pupillometric evaluation and analysis of light reflex in healthy subjects as a tool to study autonomic nervous system changes with aging
Pupillometric evaluation and analysis of light reflex in healthy subjects as a tool to study autonomic nervous system changes with aging
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DOI：
10.1007/bf03340116
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Giacomini, P
中科院分区：
文献类型：
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作者：
Pozzessere, G;Valle, E;Giacomini, P
为了评估衰老与瞳孔功能自主控制之间的关系，我们对 52 名年龄在 15-75 岁的健康志愿者进行了电视瞳孔测量和光反射评估，将其分为四个年龄组（第 1 组：15-29 岁，第 2 组：30-44 岁，第 3 组：45-59 岁，第 4 组：60-75 岁）。研究发现基线光瞳直径与年龄有关，光反射收缩速度与年龄呈线性相关。老年受试者的光反射幅度和半再扩张速度降低，但与年龄仅呈现微弱的线性相关性，而潜伏期、收缩时间和二次扩张和5秒再扩张的半再扩张时间百分比并未随年龄出现显着变化。这些结果证实，涉及瞳孔自主神经功能的机制存在重要的年龄依赖性变化，涉及交感神经和副交感神经成分。通过使用敏感且非侵入性的技术（例如电视瞳孔测量法），这些变化似乎很容易检测到。
To assess the relationships between aging and autonomic control of pupillary functions, TV-pupillometry and light reflex evaluation were performed in 52 healthy volunteers in the age range 15-75 years, grouped into four age classes (group 1: 15-29 years, Group 2: 30-44 years, Group 3: 45-59 years, Group 4: 60-75 years). Baseline light pupil diameter was found to be age-dependent, together with light reflex contraction velocity, which presented a linear correlation with age. Light reflex amplitude and half-redilatation velocity were reduced in older subjects, but presented only a weak linear correlation with age, while latency, contraction time and half-redilatation rime percent of secondary dilatation and redilatation at 5 seconds did not show significant changes with age. These results confirm that there are important age-dependent changes in the mechanisms involved in pupillary autonomic functions, regarding both sympathetic and parasympathetic components. These changes appear to be easily detectable by making use of a sensitive and non-invasive technique such as TV-pupillometry.