Behavioral, cellular, and synaptic tagging frameworks
Behavioral, cellular, and synaptic tagging frameworks
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行为、细胞和突触标记框架
DOI：
10.1016/j.nlm.2018.03.010
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发表时间：
2018
影响因子：
2.7
通讯作者：
Inokuchi Kaoru
中科院分区：
文献类型：
--
作者：
Nomoto Masanori;Inokuchi Kaoru
行为标记是将一个弱经验诱发的短时记忆通过与一个新经验的时间关联转化为长时记忆的过程。这种现象被发现在行为水平上重演了突触标记和捕获。在确定与突触标签和捕获和行为标签理论相关的分子机制方面取得了重大进展。然而，可塑性相关蛋白的标签设置和招聘，发生在时空约束的细胞系综在网络水平（细胞标签）在大脑中，多模态的感觉信息输入的地方才刚刚开始被理解。在这里，我们回顾了行为标记的证据和机制的基础上的内存分配在网络水平导致重叠的细胞合奏。我们还讨论了标准巴甫洛夫条件反射和不同的记忆协会重叠细胞合奏的功能意义。最后，我们描述了行为标记的神经元合奏重叠的作用。
Behavioral tagging is the transformation of a short-term memory induced by a weak experience into a long-term memory through temporal association with a novel experience. This phenomenon was discovered to recapitulate synaptic tagging and capture at the behavioral level. Significant progress has been made in determining the molecular machinery associated with synaptic tagging and capture and behavioral tagging theories. However, the tag setting and recruitment of plasticity-related proteins that occur within the spatiotemporally constrained cell ensemble at the network level (cellular tagging) in the brain where multimodal sensory information is input are just beginning to be understood. Here, we review the evidence for behavioral tagging and the mechanism underlying memory allocation at the network level leading to the overlap of cell ensembles. We also discuss the functional significance of overlapping cell ensembles in association of standard Pavlovian conditioning and distinct memories. Finally, we describe the role of neuronal ensemble overlap in behavioral tagging.